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  4. Recombinant Human Galactoside-binding soluble lectin 13 (LGALS13)

Recombinant Human Galactoside-binding soluble lectin 13 (LGALS13)

  • 货号：
    CSB-YP883408HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP883408HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP883408HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP883408HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP883408HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LGALS13
  • Uniprot No.：
  • 别名：
    GAL 13; Gal-13; GAL13; Galactoside binding soluble lectin 13; Galactoside-binding soluble lectin 13; Galectin-13; Galectin13; Lectin galactoside binding soluble 13; LGALS 13; LGALS13; PLAC 8; PLAC8; Placental protein 13; Placental tissue protein 13; PP13; PP13_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-139
  • 氨基酸序列
    MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF VKMVQVSRDI SLTSVCVCN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.
  • 基因功能参考文献：
    1. Galectin-13 does not bind beta-galactosides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138. PMID: 29343868
    2. First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or small for gestational age (SGA) neonates. PMID: 26910737
    3. Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. PMID: 27070577
    4. Placental protein 13 was localized to syncytiotrophoblasts in the chorionic villi and to occasional multinucleated luminal trophoblasts within converted decidual spiral arterioles in preeclampsia patients. PMID: 21989657
    5. study provides a basis for replenishing patients at risk for preeclampsia by the full length but not the truncated PP13 PMID: 25079598
    6. inadequate sensitivity as first trimester serum marker for pre-eclampsia PMID: 24786703
    7. As gal-13 with its anti-inflammatory functions plays a role in maternal immune system, a lack of gal-13 may contribute to an imbalance in inflammation processes in the placenta during pregnancy and therefore influences development of gestational diabetes. PMID: 25499680
    8. Evaluation of placental protein 13 (PP13) and risk factors as markers for predicting preeclampsia. PMID: 24607918
    9. Among singletons with severe preeclampsia, levels were significantly reduced, however, among twins, only a non-significant tendency for a reduction was recorded. PMID: 23729534
    10. Data in rats suggest that human LGALS13 plays role in maintaining uteroplacental blood flow and plays possible role in facilitating proper adaptation of maternal vasculature to pregnancy. PMID: 23406577
    11. The maternal serum level of placental protein 13 is significantly lower in Egyptian patients with pre-eclampsia compared to controls. PMID: 22460234
    12. secretion of PAPP-A, ADAM12 and PP13 is closely related to the size of the placenta in the beginning of pregnancy. After 8 weeks of pregnancy, which is the time for luteoplacental shift, the correlation disappears. PMID: 22015022
    13. PP13 is released from the syncytiotrophoblast in preterm preeclampsia and HELLP, mimicked in BeWo cells by ischemic stress, suggesting PP13 is a placental alarmin. PMID: 21596368
    14. ABO blood group can alter PP13-bioavailability in blood PMID: 21799738
    15. PP13 was best in predicting early onset pre-eclampsia with a sensitivity of 79% at a 20% false positive rate. PMID: 21652068
    16. PP13 mRNA is lower in the third trimester at the time of disease while protein level accumulates and become higher creating an unparallel change in the level of the mRNA and the corresponding protein. PMID: 21257080
    17. PP13 levels were decreased in women with preeclampsia. PMID: 21257081
    18. PP13 is a suitable stable molecule and can be treated under routine laboratory and transport temperatures. PMID: 20509161
    19. gene polymorphism is associated with an increased risk of preterm labour PMID: 19818512
    20. multiples of the gestation-specific normal median significantly lower in trisomy 18 and 13 pregnancies PMID: 19844942
    21. level in preeclampsia was significantly lower than that in controls PMID: 19813218
    22. PP13 is implicated in the pathogenesis of impaired placentation and subsequent development of early-preeclampsia but measurement of this placental product is unlikely to be useful in screening for the disease at 11-13 weeks. PMID: 19777530
    23. The primary structure of the newly sequence analysed placental tissue protein 13 (PP13) was highly homologous to several members of the beta-galactoside-binding S-type lectin (galectin) family PMID: 11742106
    24. PP13/galectin-13 may have special haemostatic and immunobiological functions at the lining of the common feto-maternal blood-spaces or developmental role in the placenta. PMID: 15009185
    25. screening of maternal PP13 levels in the first trimester is a promising diagnostic tool for the prediction of preeclampsia with high sensitivity and specificity. PMID: 17618748
    26. Decreased levels of PP13 (placental protein 13) were not significantly correlated with the studied adverse pregnancy outcomes of intrauterine growth restriction, preterm delivery, low birth weight, and intrauterine fetal demise. PMID: 18186153
    27. Maternal serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies. PMID: 18539259
    28. parallel to its decreased placental expression, an augmented membrane shedding of PP13 contributes to the increased third trimester maternal serum PP13 concentrations in women with preterm pre-eclampsia and HELLP syndrome. PMID: 18791734
    29. findings indicate that an alteration in the placental protein 13 (PP13) messenger RNA expression in the trophoblasts may be associated with the pathogenesis of preeclampsia PMID: 19087972

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  • 亚细胞定位：
    Cytoplasm. Nucleus matrix.
  • 组织特异性：
    Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.
  • 数据库链接：

    HGNC: 15449

    OMIM: 608717

    KEGG: hsa:29124

    STRING: 9606.ENSP00000221797

    UniGene: Hs.23671