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  4. Recombinant Human Fos-related antigen 1 (FOSL1)

Recombinant Human Fos-related antigen 1 (FOSL1)

  • 中文名称：
    人FOSL1重组蛋白
  • 货号：
    CSB-YP008792HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FOSL1重组蛋白
  • 货号：
    CSB-EP008792HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FOSL1重组蛋白
  • 货号：
    CSB-EP008792HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FOSL1重组蛋白
  • 货号：
    CSB-BP008792HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FOSL1重组蛋白
  • 货号：
    CSB-MP008792HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FOS L1; FOS like antigen 1; Fos related antigen 1; Fos-related antigen 1; FOSL 1; FOSL1; FOSL1 protein; FOSL1_HUMAN; FRA 1; FRA-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-271
  • 氨基酸序列
    MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. High FOS-like antigen 1 (FOSL1) expression with mutant KRAS protein lung and pancreatic cancer patients showed the worst survival outcome. PMID: 28220783
    2. Our findings indicated that functional SNP rs1892901 in FOSL1 might affect the expression of FOSL1, and ultimately increase the risk of gastric cancer. PMID: 28169308
    3. Fra1 inhibited the protein levels of Bcl2, cMyc, Survivin, and BclxL. Fra1 overexpression in intestinal mucosal epithelial cells may restrain damage repair after intestinal mucosal injury in inflammatory bowel disease remittent period through weakening the protective effect of intestinal mucosa, thus increasing the risk of recurrence. PMID: 29257201
    4. High FRA1 expression is associated with Esophageal Squamous Cell Carcinoma. PMID: 27882471
    5. constitutive activation and non-regulation of Fra-1 by bicalutamide in PC-3 cells suggested that Fra-1, probably a key component, involved in transition of aggressive androgen-independent PC-3 cells with poor prognosis. PMID: 28386843
    6. the overexpression of Fra1 disrupted inflammatory cytokine secretion by medullary thymic epithelial cells in the myasthenia gravis thymus PMID: 29807388
    7. Taken together, our results indicated that miR-449 overexpression inhibited osteogenic differentiation of HG-FFA-treated hBMSCs through the Sirt1/Fra-1 signal pathway. PMID: 29305863
    8. These findings indicate that an aberrant Wnt/beta-catenin signalling leads to the epithelial-mesenchymal transition and drug resistance of glioma via Fra1 induction, which suggests novel therapeutic strategies for the malignant disease. PMID: 28232512
    9. MUC1 enhancement of ERK activation influences FRA-1 activity to modulate tumor migration, invasion and metastasis in a subset of pancreatic cancer cases PMID: 27220889
    10. the results indicate that FRA1 promotes cancer growth through AKT, and enhances cancer cell migration through JNK/c-Jun, pinpointing FRA1 as a key integrator of JNK and AKT signaling pathways and a potential therapeutic target for squamous cell carcinoma of the skin and head and neck squamous cell carcinoma. PMID: 27144339
    11. Study shows that FOSL1 is the main immediate early AP-1 member induced by melanoma oncogenes; found that FOSL1 is involved in melanoma cell migration as well as cell proliferation and anoikis-independent growth. PMID: 28481878
    12. a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. PMID: 27685628
    13. PKCtheta;-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and breast cancer cell migration. PMID: 27816489
    14. Multivariate analysis identified Fra-1 as an independent prognostic factor. Fra-1 may be involved in the progress of hepatocellular carcinoma and could be a promising molecular candidate in the diagnosis and treatment of hepatocellular carcinoma. PMID: 28653890
    15. Up-regulation of Fra-1 appeared in retinal ganglion cells following light-induced retina damage. PMID: 27002720
    16. HGF-induced FRA1 activation is associated with the fibrosis-dependent development of Hepatocellular Carcinoma. PMID: 27134167
    17. Our results demonstrate that Fra-1 is an important determinant of the metastatic potential of human colon cancer cells, and that the Fra-1 classifier can be used as a prognostic predictor in colon cancer patients. PMID: 26646695
    18. Results suggest that Fra-1 is upregulated in lung cancer tissues and functions by affecting the P53 signaling pathway. PMID: 26549498
    19. SIRT1 expression correlated positively with Fra-1 expression, metastasis and overall survival in patients with colorectal cancer PMID: 26975631
    20. miR-195 can repress the migration and invasion of prostate cancer cells via regulating Fra-1 PMID: 26337460
    21. Results suggested that Fra-1 expression is low in cervical cancer tissues and promotes apoptosis of cervical cancer cells by p53 signaling pathway. PMID: 25651840
    22. High Fra-1 expression significantly correlates with shorter overall survival. PMID: 25666264
    23. Fra-1 induces critical changes in the expression of tgfb1 and Epithelial-to-mesenchymal transition transcription factors through direct binding to the tgfb1, zeb1 and zeb2 genomic regulatory regions. PMID: 25301070
    24. Fra1 promotes the growth of HaCaT cells in vitro by arresting the cell cycle and inhibiting cell apoptosis. PMID: 25175497
    25. Intense immunohistochemical staining of Fra-1 was observed at the tumor marginal area adjacent to inflammatory cells and in parallel with IL-6 secretion and STAT3 activation in colorectal cancer tissues. PMID: 25750173
    26. These results suggest that FOSL1 may be related to IgAN severity. PMID: 24652774
    27. FRA1 plays an important role in mediating cross talk between oncogenic RAS-ERK and TGFbeta signaling networks during tumor progression. PMID: 24658684
    28. CD44 dysregulated the activation of the Fra1 gene. The interaction of Fra-1 and CD44 may therefore be important in cervical carcinoma. PMID: 24604526
    29. we review the current knowledge of av and b3 transcriptional regulation in endothelial cells and discuss the role of FOSL1 in angiogenesis PMID: 24084233
    30. Data indicate that estrogen induced the expression of c-Jun, Fra-1, c-Fos, cyclin D1 and cyclin E1 while tamoxifen (TMX) decreased the expression. PMID: 23625206
    31. MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. PMID: 23001043
    32. Fra-1 and c-Fos have roles in supporting growth of human malignant breast tumors by activating membrane biogenesis at the cytoplasm PMID: 23301044
    33. Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis. PMID: 23483055
    34. Fra-1 mediates anti-fibrotic effects in the lung through the modulation of proinflammatory, profibrotic and fibrotic gene expression. PMID: 22911824
    35. PKCtheta signalling as an important regulator of Fra-1 accumulation in estrogen receptor positive breast cancer cells. PMID: 22286759
    36. study reports Fra-1 is highly expressed in the muscle-invasive form of bladder cancer and to a lesser extent in superficial bladder cancer; gene coding for AXL tyrosine kinase is directly upregulated by Fra-1 in bladder cancer and other cell lines; data demonstrate that AXL mediates the effect of Fra-1 on tumour cell motility but not on cell proliferation PMID: 21822309
    37. data suggest the involvement of an injury-induced Fra-1 transcription factor as a regulator of keratinocyte gene expression, which might act as an antagonistic player to restrict epithelial-driven angiogenic responses during normal skin flap integration. PMID: 21840727
    38. This study demonstrated ESCC patients positive for Fra-1 to be associated with poor prognosis. The findings also suggest that Fra-1 regulation may play an important role in the progression of ESCC. PMID: 22028113
    39. Fra-1 was induced by Epstein-Barr virus LMP2A and is essential for LMP2A-triggered MMP9 expression. PMID: 22514348
    40. A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found. PMID: 21371080
    41. the molecular data suggest that the functional outcome of the 11q12 rearrangements is deregulated expression of FOSL1. PMID: 22411068
    42. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index. High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis. PMID: 22235402
    43. Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone. PMID: 22461694
    44. identified Fra-1 as a new target of miR-34a and demonstrated that miR-34a inhibits Fra-1 expression at both protein and messenger RNA levels; p53 indirectly regulates Fra-1 expression via a miR-34a-dependant manner in colon cancer cells PMID: 22198213
    45. Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma. PMID: 21969367
    46. Fra-1 is an important mediator of interstitial lung disease following gefitinib treatment PMID: 21460858
    47. study shows that YAP could promote cell proliferation by activating transcription factor Fra-1 in oral squamous cell carcinoma. PMID: 21708480
    48. RT-PCR showed that FOSL1 from osteoblasts from Pfeiffer syndrome grown on PLPG acid plates were upregulated after 30 days. PMID: 21558934
    49. Two AP-1 components, c-Jun and Fra-1, were phosphorylated, and bound to the AP-1 binding site of the MMP-1 promoter in 143B cells. PMID: 21640141
    50. Activated nuclear factor kappaB and Fos-related antigen 1 are elevated in epithelial cells in lung tissues of patients with acute respiratory distress syndrome. PMID: 21526963

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Fos subfamily
  • 数据库链接：

    HGNC: 13718

    OMIM: 136515

    KEGG: hsa:8061

    STRING: 9606.ENSP00000310170

    UniGene: Hs.283565