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  4. Recombinant Human Forkhead box protein N3 (FOXN3)

Recombinant Human Forkhead box protein N3 (FOXN3)

  • 中文名称：
    人FOXN3重组蛋白
  • 货号：
    CSB-YP008831HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FOXN3重组蛋白
  • 货号：
    CSB-EP008831HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FOXN3重组蛋白
  • 货号：
    CSB-EP008831HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FOXN3重组蛋白
  • 货号：
    CSB-BP008831HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FOXN3重组蛋白
  • 货号：
    CSB-MP008831HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXN3
  • Uniprot No.：
  • 别名：
    C14orf116; Checkpoint suppressor 1; CHES1; Forkhead box protein N3; Foxn3; FOXN3_HUMAN; FXN3; PRO1635
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-490
  • 氨基酸序列
    MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG QKEQKETTKN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
  • 基因功能参考文献：
    1. FOXN3 bind to beta-catenin and inhibited beta-catenin/TCF signaling by blocking the interaction between beta-catenin and TCF4. Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. PMID: 28039460
    2. FOXN3 functions as a tumor suppressor in hepatocellular carcinoma by downregulating the expression of E2F5. PMID: 27259277
    3. the FOXN3-NEAT1-SIN3A complex promotes epithelial-to-mesenchymal transition and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo PMID: 28805661
    4. the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose. PMID: 27292639
    5. Foxn3 is a direct transcriptional suppressor of N-cadherin in colorectal metastasis. PMID: 26069251
    6. MEN1 patients with MEN1 mutations leading to CHES1-loss of interaction have a higher risk of malignant pancreatic neuroendocrine tumors with an aggressive course of disease and disease-related death. PMID: 25210877
    7. CHES1 decreases protein synthesis and cell proliferation in tumor cell lines but not in normal fibroblasts. PMID: 24403608
    8. MicroRNA-574-5p has a critical role in TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 PMID: 23133627
    9. the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects. PMID: 20691664
    10. Data suggest that CHES1 recruits Ski-interacting protein (SKIP) to repress genes important for tumorigenesis and the response to cancer treatments. PMID: 16102918
    11. Meninis involved in the activation of S-phase arrest in multple endocrein neoplasia by interacting with CHES1. PMID: 16951149
    12. FOXN3 might contribute to the observed phenotype. PMID: 18074379

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 1928

    OMIM: 602628

    KEGG: hsa:1112

    STRING: 9606.ENSP00000261302

    UniGene: Hs.434286