Recombinant Human Extracellular calcium-sensing receptor (CASR), partial

1. Performed cytogenetic analysis in 23 patients with Sagliker syndrome; found base alterations and deletions in exons 2 and 3 of the calcium sensing receptor (CaSR) gene. PMID: 28263480
2. Based on these findings, ischemia/reperfusion-induced MCPIP1 expression regulates the migration and apoptosis of human vascular endothelial cells via HMGB1 and CaSR, respectively. PMID: 29379093
3. expressions of p27(Kip1) and CaSR were decreased in primary hyperparathyroidism patients PMID: 29589297
4. Study presents the novel concept that CaSR activation stimulates autophagy in preadipocytes, which in turn mediates the elevation of TNFalpha production. PMID: 30251678
5. The identification of the activation of CaSR-mediated protective pathway in renal cells sheds light on a possible cellular protective mechanism against Cd-induced kidney injury. PMID: 29348484
6. These findings suggest an inhibitory role for CaSR in endometrial cancer. Therefore, reduced CaSR expression may be a suitable explanation and valuable predictor for endometrial cancer progression. PMID: 29348629
7. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype.Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population. PMID: 30407299
8. The variant allele of CASR rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced secondary hyperparathyroidism. PMID: 29763933
9. findings confirm the expression of CaSR in human BM-derived MSCs and unravel a prominent role for the interplay between CaSR and PTH1R in regulating MSC fate and the choice of pathway for bone formation. PMID: 29915064
10. Genetic polymorphism of calcium-sensing receptor is associated with breast cancer. PMID: 29387985
11. The low prevalence of CaSR autoantibodies indicate a very low level of subclinical parathyroid autoimmunity in APS types 2, 3 and 4. PMID: 28941288
12. CaSR Arg990Gly polymorphism is associated with the risk of nephrolithiasis development in a Chinese population. PMID: 28609763
13. TRPC1 is a primary candidate in forming SOCC that stimulates CaSRinduced SOCE and NO production in HUVECs PMID: 28791397
14. The c.2195A>G, p.(Asn732Ser) mutation in exon 7 of the CaSR gene leads to hypocalcaemia, and has not been reported before in the medical literature. 2) Possibly, this mutation is linked to premature baldness. PMID: 28741586
15. CASR SNPs may partly explain differences in the clinical manifestations of CKD-MBD between european and African ancestry populations, and in the biochemical response to cinacalcet in many patients. PMID: 28630081
16. Decreased sensitivity of the CaSR to calcium due to inactivating polymorphisms at rs1801725, may predispose up to 20% of breast cancer cases to high circulating calcium-associated larger and/or aggressive breast tumors. PMID: 28764683
17. This study shows that the A allele of rs7652589 is a risk allele for nephrolithiasis-related end stage renal disease. The AA genotype is associated with more severe secondary hyperparathyroidism (higher calcium and parathormone concentrations). PMID: 27739473
18. Polymorphism of the Calcium-Sensing Receptor Gene is associated with Breast Cancer Risk.[review] PMID: 29504802
19. Data show that Cao2+ via CaR- mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells. PMID: 27206800
20. GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. PMID: 27760455
21. this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 channels. Both CaSR and TRPV4 were involved in Ca2+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2+/AKT/beta-catenin relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR. PMID: 28951460
22. mutagenesis with a novel analytical approach and molecular modeling to develop an "enriched" picture of structure-function requirements for interaction between Ca(2+)o and allosteric modulators within the CaSR's 7 transmembrane (7TM) domain, is reported. PMID: 27002221
23. FLNA is downregulated in parathyroid tumors and parallels the CASR expression levels. Loss of FLNA reduces CASR mRNA and protein expression levels and the CASR-induced ERK phosphorylation. FLNA is involved in receptor expression, membrane localization and ERK signaling activation of both 990R and 990G CASR variants. PMID: 27872158
24. A father and daughter with asymptomatic chronic hypocalcemia with low parathyroid hormone and inappropriate urinary calcium excretion had a missense mutation in exon 7: c.2621G>T (p.Cys874Phe). PMID: 27663953
25. These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6. PMID: 27477783
26. These structures reveal multiple binding sites for Ca(2+) and PO4(3-) ions. Both ions are crucial for structural integrity of the receptor. While Ca(2+) ions stabilize the active state, PO4(3-) ions reinforce the inactive conformation. PMID: 27434672
27. The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. PMID: 28419469
28. Glucose acts as a positive allosteric modulator of CaSR. PMID: 27613866
29. These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass. PMID: 28575322
30. Minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma cell lines in which the CASR gene promoter P2 is not hypermethylated. PMID: 27862333
31. Calcium exerted its effects on cartilaginous endplates matrix protein synthesis through activation of the extracellular calcium-sensing receptor. PMID: 27452962
32. Polymorphic variations in VDR and CASR may be associated with survival after a diagnosis of colorectal neoplasms. PMID: 28765616
33. CaSR and AP2S1 sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases. PMID: 28176280
34. reduced expression of the CaSR is correlated with activation of the renin-angiotensin system, which induces increased vascular remodeling and vascular smooth muscle cell proliferation, and thereby associated with essential hypertension in the SHR rat model and in the Han Chinese population PMID: 27391973
35. CaSR exerts a suppressive function in pancreatic tumorigenesis through a novel NCX1/Ca(2+)/beta-catenin signaling pathway. PMID: 27108064
36. In whites, CaSR gene SNP rs1801725 was associated with serum calcium but not with risk of diabetes. PMID: 27510541
37. Tumor CaSR expression is associated with an increased risk of lethal prostate cancer, particularly in tumors with low VDR expression. PMID: 27115058
38. Functional interaction of upregulated CaSR and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling. PMID: 26968768
39. This is a prospective observational study that measures the expression of vitamin D (VD) metabolising and signalling molecules and Ca(2+) sensing receptor (CaSR) in human Fallopian tube (FT) during the menstrual cycle and ectopic pregnancy (EP). PMID: 27770255
40. CaSR expression was shown in HepG2 cells and human liver samples; CaSR may contribute to obesity-associated hepatic metabolic consequences PMID: 27565442
41. Polymorphisms of CASR gene increase the risk of primary hyperparathyroidism. PMID: 26710757
42. Calcium oxalate-induced renal injury is related to CaSR-mediated oxidative stress and increased mitogen-activated protein kinase signaling, which subsequently leads to CaOx crystal adhesion. PMID: 27965733
43. The detection of CaSR gene mutations is suitable to differentiate states of hypercalcemia and may help to avoid invasive procedures such as parathyroidectomies. PMID: 27926951
44. a novel loss-of-function mutation, G571W, in the CaSR gene in a Korean family with familial hypocalciuric hypercalcemia. PMID: 26386835
45. There is a significant correlation between in vitro functional impairment of the CaSR at physiologic calcium concentrations and the severity of alterations in calcium homeostasis in patients. PMID: 27666534
46. Calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer. PMID: 25124570
47. physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR. PMID: 26911344
48. CaSR and PTH1R signaling responses in cartilage and bone. [review] PMID: 26688334
49. The calcium-sensing receptor may be involved in the modulation of inflammatory processes. [review] PMID: 26303192
50. A986S polymorphism of CaSR is an independent predictor of PTH level in normocalcemic hyperparathyroidism patients, but not in asymptomatic hyperparathyroidism. PMID: 26332755

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HGNC: 1514

OMIM: 145980

KEGG: hsa:846

STRING: 9606.ENSP00000420194

UniGene: Hs.435615