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  4. Recombinant Human Endophilin-A2 (SH3GL1)

Recombinant Human Endophilin-A2 (SH3GL1)

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  • 中文名称：
    人SH3GL1重组蛋白
  • 货号：
    CSB-EP859949HUb0
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 containing Grb 2 like 1 protein; SH3 containing protein EEN; SH3 domain GRB2 like 1; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3D2B; SH3G1_HUMAN; Sh3gl1; SH3P8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    45.0 kDa
  • 表达区域：
    1-368aa
  • 氨基酸序列
    MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLPQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
  • 基因功能参考文献：
    1. Study observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-alpha in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. PMID: 29113429
    2. Our study provides novel evidence of Endo II function in HER2+ cancer cell motility and trafficking of HER2 that relates to effective treatments with trastuzumab or T-DM1. Thus, differential expression of Endo II may relate to sensitivity or resistance to trastuzumab-based therapies for HER2+ cancers PMID: 28974266
    3. Expression level of SH3GL1 was widely upregulated in human OS tissues, and their overexpression was significantly correlated with more aggressive clinicopathological features. PMID: 28702842
    4. Endophilin-A2 was identified as a novel molecule regulating macrophage-derived foam cell formation by mechanisms attributable to clathrin-mediated endocytosis and beyond clathrin-mediated endocytosis PMID: 27741419
    5. inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR/ERK/AP-1 pathway. PMID: 27220321
    6. Endo II expression was highest in triple-negative breast cancers tumors compared with other subtypes, and at the level of gene expression, high Endo II was associated with reduced relapse-free survival in patients with basal-like breast cancers. PMID: 25784716
    7. results establish a novel function of endoA2 in clathrin-independent endocytosis PMID: 25517096
    8. these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. PMID: 24704450
    9. MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells. PMID: 23970061
    10. SH3GL1 may be involved in the oncogenic process of gliomas and effectively elicit an autologous antibody response in low-grade gliomas. PMID: 23050879
    11. Two endophilin A2 mutants, E264A and E264R, have different effects on how endophilin interacts with other proteins, such as dynamin or beta1-adrenergic receptors. PMID: 22750032
    12. Idiopathic scoliosis is a multifactorial genetic disease and SH3GL1 may be one of the pathogenic genes for this disease. PMID: 22183150
    13. SH3GL1 is possibly one of the disease associated genes of adolescent idiopathic scoliosis. PMID: 20627007
    14. new mechanism for MLL-EEN-mediated leukemogenesis in which MLL-EEN interferes with the Ras-suppressing activities of EBP through direct interaction. PMID: 14551139
    15. EEN part plays an essential role in leukemogenesis caused by MLL-EEN. PMID: 15077184
    16. Our results suggest that distinct subcellular localization of the endophilin A family members probably underpins their diverse cellular functions and indicates a role for EEN/EA2 in the cell cycle. PMID: 15214844
    17. findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain PMID: 15944398

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  • 相关疾病：
    In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.
  • 亚细胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein. Cell projection, podosome.
  • 蛋白家族：
    Endophilin family
  • 组织特异性：
    Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.
  • 数据库链接：

    HGNC: 10830

    OMIM: 601768

    KEGG: hsa:6455

    STRING: 9606.ENSP00000269886

    UniGene: Hs.490415