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  4. Recombinant Human Embryonic growth/differentiation factor 1 (GDF1)

Recombinant Human Embryonic growth/differentiation factor 1 (GDF1)

  • 中文名称：
    人GDF1重组蛋白
  • 货号：
    CSB-YP009342HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GDF1重组蛋白
  • 货号：
    CSB-EP009342HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GDF1重组蛋白
  • 货号：
    CSB-EP009342HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GDF1重组蛋白
  • 货号：
    CSB-BP009342HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GDF1重组蛋白
  • 货号：
    CSB-MP009342HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GDF1
  • Uniprot No.：
  • 别名：
    DORV; DTGA3; Embryonic growth/differentiation factor 1; GDF 1; GDF-1; GDF1; GDF1_HUMAN; Growth differentiation factor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    254-372
  • 氨基酸序列
    DAEPVLG GGPGGACRAR RLYVSFREVG WHRWVIAPRG FLANYCQGQC ALPVALSGSG GPPALNHAVL RALMHAAAPG AADLPCCVPA RLSPISVLFF DNSDNVVLRQ YEDMVVDECG CR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    May mediate cell differentiation events during embryonic development.
  • 基因功能参考文献：
    1. Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects. PMID: 26656983
    2. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2. PMID: 24798330
    3. indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts. PMID: 24275554
    4. GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population. PMID: 23076529
    5. Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1. PMID: 20413652
    6. Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries. PMID: 17924340
    7. GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy. PMID: 19359031

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  • 相关疾病：
    Conotruncal heart malformations (CTHM); Transposition of the great arteries dextro-looped 3 (DTGA3); Tetralogy of Fallot (TOF); Right atrial isomerism (RAI)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Expressed in the brain.
  • 数据库链接：

    HGNC: 4214

    OMIM: 187500

    KEGG: hsa:2657

    STRING: 9606.ENSP00000247005

    UniGene: Hs.412355