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  4. Recombinant Human Doublecortin domain-containing protein 2 (DCDC2)

Recombinant Human Doublecortin domain-containing protein 2 (DCDC2)

  • 中文名称：
    Recombinant Human Doublecortin domain-containing protein 2(DCDC2),Yeast
  • 货号：
    CSB-YP887036HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Doublecortin domain-containing protein 2(DCDC2),Yeast
  • 货号：
    CSB-EP887036HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Doublecortin domain-containing protein 2(DCDC2),Yeast
  • 货号：
    CSB-EP887036HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Doublecortin domain-containing protein 2(DCDC2),Yeast
  • 货号：
    CSB-BP887036HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Doublecortin domain-containing protein 2(DCDC2),Yeast
  • 货号：
    CSB-MP887036HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DCDC2
  • Uniprot No.：
  • 别名：
    DCDC 2; DCDC2; DCDC2_HUMAN; DCDC2A; Doublecortin domain containing 2; doublecortin domain containing protein 2; Doublecortin domain-containing protein 2; HGNC:18141; KIAA1154; Protein RU2S; RU 2; RU2; RU2S; RU2S protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-476
  • 氨基酸序列
    MSGSSARSSH LSQPVVKSVL VYRNGDPFYA GRRVVIHEKK VSSFEVFLKE VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI QSGGNYVAGG QEAFKKLNYL DIGEIKKRPM EVVNTEVKPV IHSRINVSAR FRKPLQEPCT IFLIANGDLI NPASRLLIPR KTLNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE LENGQFYVAV GRDKFKKLPY SELLFDKSTM RRPFGQKASS LPPIVGSRKS KGSGNDRHSK STVGSSDNSS PQPLKRKGKK EDVNSEKLTK LKQNVKLKNS QETIPNSDEG IFKAGAERSE TRGAAEVQED EDTQVEVPVD QRPAEIVDEE EDGEKANKDA EQKEDFSGMN GDLEEEGGRE ATDAPEQVEE ILDHSEQQAR PARVNGGTDE ENGEELQQVN NELQLVLDKE RKSQGAGSGQ DEADVDPQRP PRPEVKITSP EENENNQQNK DYAAVA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.
  • 基因功能参考文献：
    1. Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages. PMID: 29666269
    2. Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2 PMID: 29028086
    3. By suggesting the presence of common biological processes underlying reading (dis)ability, these findings represent initial support for a generalist effect of the non-additive interdependence between READ1 and the KIAA0319 risk haplotype and can help in clinically assessing the individual risk for Developmental dyslexia. PMID: 29066855
    4. Neonatal sclerosing cholangitis patients in substantial proportion harbour mutations in DCDC2. PMID: 27469900
    5. Study concludes that DCDC2 deletion is not a strong risk factor for dyslexia. PMID: 28742079
    6. The study corroborates the importance of rs7765678-DCDC2 among others in the aetiology of dyslexia in a German case-control cohort. PMID: 27312598
    7. Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect. PMID: 27319779
    8. Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect. PMID: 27501527
    9. that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium PMID: 27451412
    10. DCDC2 Polymorphism is associated with reading disability. PMID: 27100778
    11. off-target, non-immune mediated effects of the mTOR-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 in glomerular podocyte development PMID: 26331477
    12. This study demonstrated that DCDC2 intron 2 deletion impair illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with Developmental dyslexia. PMID: 25270309
    13. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (corrected P = 0.016) showed a significant association with spelling performance in families of German origin. PMID: 25877001
    14. Our results reveal DCDC2a to be a deafness gene and a player in hair cell kinocilia and supporting cell primary cilia length regulation likely via its role in microtubule formation and stabilization. PMID: 25601850
    15. the association of DCDC2 and KIAA0319 with Developmental dyslexia in Chinese population should be further validated PMID: 25230923
    16. In a population carrying a deletion in the DCDC2 gene, impaired motion perception was identified in subjects with dyslexia. PMID: 26019324
    17. DCDC2d is associated with altered fractional anisotropy PMID: 24926531
    18. Among children exposed to low socioeconomic level, READ1 [regulatory element associated with dyslexia 1 ] genetic variant targets the worst outcome in children's attention. PMID: 25012462
    19. DCDC2 interacts with the mediator of Wnt signaling dishevelled, and that DCDC2 overexpression inhibits beta-catenin-dependent Wnt signaling; central role of Wnt signaling in the pathogenesis of nephronophthisis-related ciliopathies PMID: 25557784
    20. An SNP in DCDC2 (rs793842) was significantly associated with the thickness of the left temporoparietal cortex. PMID: 25339756
    21. This study demonstrated the association of developmental dyslexia with rs4504469 of KIAA0319 and not with any single-nucleotide polymorphisms of DCDC2. PMID: 23677054
    22. BV677278 is a regulatory element that influences reading and language skills. PMID: 23746548
    23. In prostate cancer cells, DCDC2 colocalized with microtubules and promoted cell migration and resistance to the microtubule-targeting drug taxol.DCDC2 is aberrantly expressed in prostate cancers. PMID: 22733135
    24. DCDC2 rs807701 might contribute significantly to dyslexia risk. PMID: 23229871
    25. The results of this study found that DCDC2 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. PMID: 22683091
    26. Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia. PMID: 22558177
    27. DCDC2 influences both reading and memory impairments. PMID: 21881542
    28. The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han Chinese. PMID: 22490485
    29. We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities PMID: 21457949
    30. DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia PMID: 21698230
    31. This study demonistrated that The superior prefrontal, temporal and occipital networks were positively related to DCDC2 in the schizophrenia, but not the control group. PMID: 21507613
    32. Five alleles displayed strong enhancer activity and increased gene expression, while allele 1 showed no enhancer activity. These studies suggest that the association of BV677278 with RD reflects a role as a modifier of DCDC2 expression. PMID: 21042874
    33. We identified four rare variants that were significantly associated with the late MMN component. PMID: 21104116
    34. No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. PMID: 21046216
    35. At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample. PMID: 21203818
    36. DCDC2 is a risk gene for reading disorder. PMID: 20068590
    37. DCDC2 is proposed as a candidate gene for reading disability. PMID: 16278297
    38. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. PMID: 16385449
    39. A slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands, was observed. PMID: 17450541
    40. we found a nominally significant association for the quantitative dimension "word reading" and dcdc2 genotype PMID: 18810304
    41. conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified PMID: 19018237
    42. suspected dyslexia-associated gene PMID: 19238550
    43. Our data suggest that the causal variants for ADHD might be found in the VMP/DCDC2 region PMID: 19362708

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  • 相关疾病：
    Dyslexia 2 (DYX2); Nephronophthisis 19 (NPHP19); Deafness, autosomal recessive, 66 (DFNB66); Sclerosing cholangitis, neonatal (NSC)
  • 亚细胞定位：
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, kinocilium. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus. Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein
  • 数据库链接：

    HGNC: 18141

    OMIM: 600202

    KEGG: hsa:51473

    STRING: 9606.ENSP00000367715

    UniGene: Hs.61345