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  4. Recombinant Human DnaJ homolog subfamily C member 12 (DNAJC12)

Recombinant Human DnaJ homolog subfamily C member 12 (DNAJC12)

  • 中文名称：
    人DNAJC12重组蛋白
  • 货号：
    CSB-YP892329HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DNAJC12重组蛋白
  • 货号：
    CSB-EP892329HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DNAJC12重组蛋白
  • 货号：
    CSB-EP892329HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DNAJC12重组蛋白
  • 货号：
    CSB-BP892329HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DNAJC12重组蛋白
  • 货号：
    CSB-MP892329HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DNAJC12
  • Uniprot No.：
  • 别名：
    DJC12_HUMAN; DnaJ (Hsp40) homolog subfamily C member 12; DnaJ heat shock protein family (Hsp40) member C12; DnaJ homolog subfamily C member 12; DnaJ/Hsp40 homolog; subfamily C; member 12; DNAJC12; HPANBH4; J domain containing protein 1 (JDP1); J domain containing protein 1; J domain protein 1; J domain-containing protein 1; JDP1; mJDP1; RP11-57G10.2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-198
  • 氨基酸序列
    MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR WSKDAPSELL RKFRNYEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Molecular diagnostics for DNAJC12 variants are thus mandatory in all patients in which deficiencies of PAH and BH4 are genetically excluded. PMID: 29174366
    2. DNAJC12 mutation is not a risk factor of Parkinson's disease in Chinese Han population. PMID: 29801756
    3. The results of this study suggest that DNAJC12 mutations (absent in 500 early-onset patients with Parkinson's disease) rarely cause dopa-responsive nonprogressive parkinsonism in adulthood. PMID: 28892570
    4. We report biallelic mutations of DNAJC12 in six affected individuals from four families with hyperphenylalaninemia and dopamine and serotonin deficiencies not caused by mutations in phenylalanine hydroxylase or any known tetrahydrobiopterin metabolism genes. PMID: 28132689
    5. High expression of DNAJC12 correlates with poor prognosis for rectal cancer. PMID: 25805104
    6. the endogenous DNAJC12 and Hsc70 proteins interact in LNCaP cells. PMID: 24122553
    7. JDP1 is a estrogen target gene and that its expression might be used as a marker of the estrogen transactivation activity PMID: 16391838

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  • 相关疾病：
    Hyperphenylalaninemia, mild, non-BH4-deficient (HPANBH4)
  • 亚细胞定位：
    [Isoform a]: Cytoplasm.
  • 组织特异性：
    Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach.
  • 数据库链接：

    HGNC: 28908

    OMIM: 606060

    KEGG: hsa:56521

    STRING: 9606.ENSP00000225171

    UniGene: Hs.260720