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  4. Recombinant Human Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3)

Recombinant Human Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3)

  • 中文名称：
    人NUDT3重组蛋白
  • 货号：
    CSB-YP530966HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NUDT3重组蛋白
  • 货号：
    CSB-EP530966HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NUDT3重组蛋白
  • 货号：
    CSB-EP530966HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NUDT3重组蛋白
  • 货号：
    CSB-BP530966HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NUDT3重组蛋白
  • 货号：
    CSB-MP530966HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NUDT3
  • Uniprot No.：
  • 别名：
    5''''-P1; Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1; Diadenosine 5''; Diphosphoinositol polyphosphate phosphohydrolase 1; Diphosphoinositol polyphosphate phosphohydrolase; DIPP 1; DIPP; DIPP-1; DIPP1; Nucleoside diphosphate linked moiety X motif 3; Nucleoside diphosphate-linked moiety X motif 3; Nudix (nucleoside diphosphate linked moiety X) type motif 3; Nudix motif 3; Nudix type motif 3; NUDT 3; Nudt3; NUDT3_HUMAN; P6-hexaphosphate hydrolase 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-172
  • 氨基酸序列
    MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility.
  • 基因功能参考文献：
    1. Nudt3 is an mRNA decapping enzyme that orchestrates expression of a subset of mRNAs to modulate cell migration and further substantiates the existence of multiple decapping enzymes functioning in distinct cellular pathways in mammals PMID: 26932476
    2. results suggest that NUDT3 rs206936 is associated with body mass index in Japanese women PMID: 23708086
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Nudix hydrolase family, DIPP subfamily
  • 组织特异性：
    Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • 数据库链接：

    HGNC: 8050

    OMIM: 609228

    KEGG: hsa:11165

    STRING: 9606.ENSP00000351650

    UniGene: Hs.188882