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  4. Recombinant Human Dipeptidyl aminopeptidase-like protein 6 (DPP6), partial

Recombinant Human Dipeptidyl aminopeptidase-like protein 6 (DPP6), partial

  • 中文名称：
    人DPP6重组蛋白
  • 货号：
    CSB-YP007140HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DPP6重组蛋白
  • 货号：
    CSB-EP007140HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DPP6重组蛋白
  • 货号：
    CSB-EP007140HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DPP6重组蛋白
  • 货号：
    CSB-BP007140HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DPP6重组蛋白
  • 货号：
    CSB-MP007140HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DPP6
  • Uniprot No.：
  • 别名：
    DPP6Dipeptidyl aminopeptidase-like protein 6; DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI; DPP VI
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.
  • 基因功能参考文献：
    1. A novel missense mutation (c.1578G>C/p.Q526H) of DPP6 was identified and co-segregated with affected patients in a family with suspicious idiopathic ventricular fibrillation. PMID: 29474731
    2. These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders. PMID: 27759917
    3. we expanded our knowledge of familial IVF linked to the DPP6 gene and discuss its (extended) clinical characteristics. In addition, its relationship with the Purkinje network is further explored. PMID: 26681609
    4. This first familial case provides evidence for association between DPP6 haploinsufficiency and Gilles de la Tourette syndrome. PMID: 25129042
    5. the cysteine-rich domain of DPP6 plays an important role in protein folding of DPP6 that is required for transport of DPP6/Kv4.2 complexes out of the ER PMID: 25190807
    6. DPP6 is critical for synaptic integration and excitation. PMID: 24677629
    7. Two DPP6 de novo deletions and one missense mutation in familial microcephalic patients were identified. PMID: 23832105
    8. WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude PMID: 24225951
    9. Findings of this study indicate that an altered response of Kv4/DPP6 to long-term neuroleptic administration is involved in neuroleptic-induced TD. PMID: 21826085
    10. DPP6-mediated Purkinje fibers early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation. PMID: 23532596
    11. These results, inflated by the limited sample size determined by the rarity of this condition, suggest a possible role of this gene in the susceptibility to PrMS, at least in Southern Europeans. PMID: 23069673
    12. Antibodies to DPPX are associated with a protracted encephalitis characterized by central nervous system hyperexcitability. PMID: 23225603
    13. Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients. PMID: 22479372
    14. There was no evidence of association of dipeptidyl-peptidase 6 alleles with amyotrophic lateral sclerosis. Our negative results agree with those recently reported in additional Polish and Italian cohorts. PMID: 19525032
    15. KV4.2 channel fast inactivation induced by DPP10a or DPP6a is mediated by a common N-terminal inactivation motif via a pore-blocking mechanism. PMID: 19901547
    16. a genome-wide association study of amyotrophic lateral sclerosis identified the DPP6 locus as a candidate for more in-depth studies PMID: 20685689
    17. This study indicated that mutations in dpp6 genes are unlikely to be a common cause of ALS in the French and French Canadian populations. PMID: 20001489
    18. DPP6 expression seems to be critical for the expression of a high-frequency electrophysiological phenotype in cerebellar granule cells by increasing leak conductance, A-type current levels and kinetics, and Na(+) current amplitude. PMID: 20573902
    19. The rs10260404 polymorphism is not associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese patients. PMID: 20137488
    20. DPPX is an essential component of the native cardiac I(to) channel complex in human heart PMID: 15890703
    21. The emerging diversity of DPPX splice variants, differing only in the N-terminus of the protein, opens up intriguing possibilities for the modulation of Kv4 channels. PMID: 16764835
    22. The strongest association for ALS was a variant in the gene encoding DPP6. PMID: 18057069
    23. Study identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis in different populations of European ancestry, with an overall P value of 5.04 x 10(-8.) PMID: 18084291
    24. biophysical and biochemical methods indicate that I(SA) channels carry four subunits each of Kv4.2 and DPP6. PMID: 18364354
    25. demonstrated a 20-fold increase in DPP6 mRNA levels in the myocardium of familial idiopathic ventricular fibrillation carriers as compared to controls PMID: 19285295
    26. Genetic variation in DPP6, which is located in intron 3 and expressed predominantly in the nervous system, may be a risk factor for susceptibility to progressive spinal muscular atrophy. PMID: 19332697
    27. REVIEW: role in health and disease PMID: 19676137
    28. Analysis of the differential expression of two distinct forms of mRNA for the cow and rat orthologs. Names the variants S and L. PMID: 1729689

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  • 相关疾病：
    Familial paroxysmal ventricular fibrillation 2 (VF2); Mental retardation, autosomal dominant 33 (MRD33)
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase S9B family
  • 组织特异性：
    Expressed predominantly in brain.
  • 数据库链接：

    HGNC: 3010

    OMIM: 126141

    KEGG: hsa:1804

    STRING: 9606.ENSP00000367001

    UniGene: Hs.490684