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  4. Recombinant Human Dendritic cell nuclear protein 1 (DCNP1)

Recombinant Human Dendritic cell nuclear protein 1 (DCNP1)

  • 中文名称：
    Recombinant Human Dendritic cell nuclear protein 1(DCNP1),Yeast
  • 货号：
    CSB-YP837454HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Dendritic cell nuclear protein 1(DCNP1),Yeast
  • 货号：
    CSB-EP837454HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Dendritic cell nuclear protein 1(DCNP1),Yeast
  • 货号：
    CSB-EP837454HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Dendritic cell nuclear protein 1(DCNP1),Yeast
  • 货号：
    CSB-BP837454HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Dendritic cell nuclear protein 1(DCNP1),Yeast
  • 货号：
    CSB-MP837454HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DCANP1
  • Uniprot No.：
  • 别名：
    DCANP1; C5orf20; DCNP1; Dendritic cell nuclear protein 1; Dendritic cell nuclear protein-1; Dendritic cell-associated nuclear protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-244
  • 氨基酸序列
    MHYGAATHIQ NSRSHGLETV PGHQRLERGA GGETPEFPGC HSPAPPENFG NELLPLSAPL QGLSEGLYPP GRNKTLPAGV LREGAVQFLH RGLCNSNLSS EASARPSGTQ DELHSSRRKT GQTRREGARK HLVCSFRLYP FTVHTVSPGN SHLALYQVFK AVKLCPSETS FFLSRKSLKS SDPWHPPSLS PNSWNRQAGF RAWSSHLISL SLTCSDSQSR RVSSSQQPPL HSLSSHRRAA HVPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.
  • 基因功能参考文献：
    1. Our study reveals a connection between the major depression candidate protein DCNP1, circadian system and melatonin biosynthesis, which may contribute to the pathogenesis of depression. PMID: 29219947
    2. In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD. PMID: 23619526
    3. We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus. PMID: 20693543
    4. molecular cloning and immunocytochemical analysis PMID: 11798177
    5. Marker rs12520799, in dendritic cell nuclear protein 1 on chromosome 5, yielded a significant association with lifetime major depression. PMID: 16189510
    6. the genetic polymorphism of DCNP1 may influence production of specific IgE by altering DC (Dendritic Cells)functions in the mite allergen presenting and/or processing. PMID: 17460725

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at
  • 数据库链接：

    HGNC: 24459

    OMIM: 609710

    KEGG: hsa:140947

    UniGene: Hs.152477