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  4. Recombinant Human Delta-aminolevulinic acid dehydratase (ALAD)

Recombinant Human Delta-aminolevulinic acid dehydratase (ALAD)

  • 中文名称：
    Recombinant Human Delta-aminolevulinic acid dehydratase(ALAD),Yeast
  • 货号：
    CSB-YP001558HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Delta-aminolevulinic acid dehydratase(ALAD),Yeast
  • 货号：
    CSB-EP001558HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Delta-aminolevulinic acid dehydratase(ALAD),Yeast
  • 货号：
    CSB-EP001558HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Delta-aminolevulinic acid dehydratase(ALAD),Yeast
  • 货号：
    CSB-BP001558HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Delta-aminolevulinic acid dehydratase(ALAD),Yeast
  • 货号：
    CSB-MP001558HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ALAD
  • Uniprot No.：
  • 别名：
    ALAD; ALADH; ALADR; Aminolevulinate dehydratase ; Aminolevulinate; delta; dehydratase; Delta aminolevulinic acid dehydratase ; Delta-aminolevulinic acid dehydratase; HEM2_HUMAN; Lv; MGC5057; OTTMUSP00000009376; OTTMUSP00000009377; PBGS; Porphobilinogen synthase; RP11-10I9.1; RP24-189G18.9
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-330
  • 氨基酸序列
    MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTDV PDDIQPITSL PGVARYGVKR LEEMLRPLVE EGLRCVLIFG VPSRVPKDER GSAADSEESP AIEAIHLLRK TFPNLLVACD VCLCPYTSHG HCGLLSENGA FRAEESRQRL AEVALAYAKA GCQVVAPSDM MDGRVEAIKE ALMAHGLGNR VSVMSYSAKF ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR DVREGADMLM VKPGMPYLDI VREVKDKHPD LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV LEAMTAFRRA GADIIITYYT PQLLQWLKEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
  • 基因功能参考文献：
    1. ALAD genetic polymorphisms contribute to high blood lead levels in occupational exposed workers and may predict risk of lead poisoning. PMID: 30025905
    2. The delta-aminolevulinate dehydratase activity was significantly lower in pregnant women with gestational diabetes mellitus. PMID: 29148924
    3. The ALAD gene influences bone density among lead workers. PMID: 29028685
    4. The frequencies of genotype and allelic variants of ALAD rs1800435 did not differ significantly between patients with essential tremor (ET) and controls, and were not influenced by gender. Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET. PMID: 28276576
    5. ALAD SNP rs818708 is significantly associated with risk of lead poisoning. PMID: 28960093
    6. Overexpression of delta-aminolevulinate dehydratase (ALAD)suppresses breast cancer cell proliferation and invasion and inhibits the epithelial-mesenchymal transition phenotype. PMID: 28403546
    7. Delta-aminolevulinate dehydratase activity and oxidative stress markers were significantly lowered in preeclampsia. PMID: 27657831
    8. Results show statistically significant association between the maternal ALAD G177C polymorphism and placental lead levels. PMID: 26701682
    9. Maternal ALAD gene polymorphism can affect early neonatal neurobehavioral development by influencing the blood lead level. PMID: 26261627
    10. Genetic variation of ALAD is associated with blood lead level. PMID: 25820613
    11. This study investigated the delta-aminolevulinate dehydratase (delta-ALA-D) activity in whole blood as well as the parameters of oxidative stress, in lung cancer. PMID: 24855033
    12. Blood lead level affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx genes. PMID: 26275098
    13. Study reveals relationship between ALAD genetic polymorphisms and basic lead toxicological parameters in occupationally exposed workers. PMID: 25963508
    14. This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity PMID: 25514583
    15. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect. PMID: 25528913
    16. The results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of urinary aminolevulinic acid for environmentally lead exposed boys. PMID: 25460652
    17. Report the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers. PMID: 24631795
    18. Genetic variation in ALAD may modify associations between Pb and prostate cancer PMID: 24500903
    19. The results lend support to the notion that ALAD polymorphism exerts no marked impact on lead body burden. PMID: 24156693
    20. Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype. PMID: 22851944
    21. distribution of a single nucleotide polymorphism in two populations from the Iberian Peninsula PMID: 22298357
    22. Polymorphisms of ALAD and VDR gene may play an important role in lead nephrotoxicity in high lead-exposed workers. PMID: 19548578
    23. This study demonostrated that modification by the genes ALAD lead-induced cognitive effects in children. PMID: 22101007
    24. ALAD genotype modifies the relationship between Pb and its toxic effects on the peripheral nervous system. This must be considered in the assessment of risks at Pb exposure. PMID: 21439310
    25. association between oxidative stress, abnormalities on lipid profile, distribution of body fat and delta-ALA-D activity inhibition; the enzyme is more oxidized in the DM2 patient PMID: 21762684
    26. ALAD2 and hPEPT2*2 polymorphisms may exaggerate Pb blood burden in boys. PMID: 21327641
    27. A common genetic variation in ALAD may alter the risk of renal cell carcinoma PMID: 21799727
    28. Examined whether the ALAD G177C single nucleotide polymorphism (SNP) affects the relationship between lead and mortality; observed no convincing interaction effect between ALAD genotype and blood lead level on mortality risk. PMID: 21293208
    29. Study suggests that the lead-exposure-induced increases in ALAD methylation may be involved in the mechanism of lead toxicity. PMID: 21396434
    30. Lead-exposed workers with the ALAD2 allele appear to be more susceptible to the effects of lead on renal injury, whereas neurobehavioral functions in ALAD1 homozygote tend to be more vulnerable. PMID: 20510440
    31. blood lead levels may be an important risk factor for hypertension and increased systolic and diastolic blood pressure. These associations may be modified by ALAD genotype. PMID: 20123609
    32. ALAD has a major and limiting role in regulating protoporphyrin IX synthesis and photodynamic therapy outcome. PMID: 19789817
    33. Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid PMID: 11909869
    34. CYP2E1 overexpression up-regulates both this enzyme and heme oxygenase-1 in a human hepatoma cell line. PMID: 12469218
    35. The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner. PMID: 14694653
    36. A cross-sectional evaluation of differences of hematologic parameters by ALAD genotype in male lead workers from Korea. PMID: 15064157
    37. Finds no association of animolevulinic acid dehydratase polymorphisms with patella lead concentrations in lead workers. PMID: 15213514
    38. ALAD polymorphisms not found to be associated with levels of blood lead and blood zinc protoporphyrin in lead workers PMID: 15258767
    39. The Porphobilinogen synthase (PBGS) catalyzes the first common reaction in the biosynthesis of the tetrapyrroles, the asymmetric condensation of two molecules of delta-aminolevulinic acid to form porphobilinogen PMID: 15381398
    40. Octameric and hexameric morpheeins of PBGS are very close in energy. Also, W19A assembles into a mixture of dimers, which appear to be stable. PMID: 16377642
    41. significant interethnic differences in the distribution of G177C ALAD variants found in the Brazilian population is consistent with differences previously reported in other countries PMID: 16445899
    42. Homozygote Rsa and Rsa39488 ALAD 2-2 seems to offer some protection against the effect of lead on motor dexterity function. PMID: 16730797
    43. Results point out that there is a correlation among diabetes, hypothyroidism and delta-ALA-D activity. PMID: 17291479
    44. A negative correlation was found between the alteration in delta-ALA-D activity and oxidative stress PMID: 17383846
    45. study found that ALAD polymorphism had a small or only modest effect on blood lead levels in Thai workers who were exposed to lead PMID: 17649958
    46. ALAD 1-1 carriers exhibit a greater likelihood than ALAD 1-2/2-2 carriers of psychiatric symptoms at a higher lead burden. PMID: 17823382
    47. certain ALAD genotypes may affect the susceptibility of humans to lead PMID: 17966070
    48. The morpheein equilibria of wild type (WT) human PBGS are found to respond to changes in pH, PBGS concentration, and substrate turnover. PMID: 18271513
    49. Pregnancy is associated with increased plasma lead/whole blood lead ratio in ALAD 1-1 genotype. PMID: 18282196
    50. A significant difference was seen in the frequency distribution of ALAD genotype between Uygur and Han races. The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner. PMID: 18795909

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  • 相关疾病：
    Acute hepatic porphyria (AHEPP)
  • 蛋白家族：
    ALAD family
  • 数据库链接：

    HGNC: 395

    OMIM: 125270

    KEGG: hsa:210

    STRING: 9606.ENSP00000386284

    UniGene: Hs.1227