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  4. Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4), partial

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4), partial

  • 货号：
    CSB-YP844735HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP844735HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP844735HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP844735HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP844735HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    1700012K17Rik; AIbZIP; Androgen induced basic leucine zipper; Androgen induced basic leucine zipper protein; Androgen-induced basic leucine zipper protein; ATCE1; Attaching to CRE like 1; Attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 3 like 4; cAMP responsive element binding protein 4; cAMP responsive element-binding protein 3 like protein 4; cAMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CR3L4_HUMAN; CREB 4; CREB-4; CREB3; CREB3L4; CREB4; Cyclic AMP responsive element binding protein 3 like protein 4; Cyclic AMP responsive element binding protein 4; Cyclic AMP-responsive element-binding protein 4; hJAL; JAL; mJAL; Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Tisp40; Tisp40alpha; Tisp40beta; Transcript induced in spermiogenesis protein 40
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
  • 基因功能参考文献：
    1. CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding. PMID: 28338058
    2. AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells. PMID: 27853318
    3. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. PMID: 11830526
    4. identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues PMID: 12111373
    5. S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region PMID: 16236796
    6. In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis. PMID: 17712038

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than
  • 数据库链接：

    HGNC: 18854

    OMIM: 607138

    KEGG: hsa:148327

    STRING: 9606.ENSP00000271889

    UniGene: Hs.372924