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  4. Recombinant Human Crumbs protein homolog 3 (CRB3), partial

Recombinant Human Crumbs protein homolog 3 (CRB3), partial

  • 中文名称：
    Recombinant Human Crumbs protein homolog 3(CRB3),partial,Yeast
  • 货号：
    CSB-YP866285HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Crumbs protein homolog 3(CRB3),partial,Yeast
  • 货号：
    CSB-EP866285HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Crumbs protein homolog 3(CRB3),partial,Yeast
  • 货号：
    CSB-EP866285HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Crumbs protein homolog 3(CRB3),partial,Yeast
  • 货号：
    CSB-BP866285HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Crumbs protein homolog 3(CRB3),partial,Yeast
  • 货号：
    CSB-MP866285HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CRB3
  • Uniprot No.：
  • 别名：
    CRB3; CRUM3_HUMAN; crumbs homolog 3 (Drosophila); Crumbs protein homolog 3; crumbs, Drosophila, homolog of, 3; PRO1158; protein crumbs homolog 3; UNQ588
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7.
  • 基因功能参考文献：
    1. we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra and/or FRMD6, in mammary epithelial cells. PMID: 28079891
    2. Data show different intracellular mobility patterns for crumbs 3 proteins Crb3A and Crb3B. PMID: 26975581
    3. our data demonstrated that CRB3 may be used as a new independent favorable prognostic factor for human ccRCC PMID: 25406012
    4. CRB3, through its cytoplasmic domain and its interactors, plays a role in apical membrane morphogenesis and tight junction regulation. PMID: 14718572
    5. The crumbs3 protein plays an important role in epithelial tight junction formation, and also provide the first known functional role for the mammalian Crumbs FERM binding domain. PMID: 15976445
    6. Data show that a novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta1 interactions. PMID: 17646395
    7. overexpression of human CRB1 and related isoforms, CRB2 and CRB3, had no effect on the levels of presenilin complex components, on NCT maturation or on PS endoproteolysis PMID: 17988153

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  • 亚细胞定位：
    Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
  • 组织特异性：
    Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, and colon. Expressed at high levels in retina, colon and mammary glands. Moderately expressed in liver, spleen, pancreas and prostate. Moderately to weakly expressed
  • 数据库链接：

    HGNC: 20237

    OMIM: 609737

    KEGG: hsa:92359

    UniGene: Hs.150319