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  4. Recombinant Human Complement factor H-related protein 4 (CFHR4)

Recombinant Human Complement factor H-related protein 4 (CFHR4)

  • 中文名称：
    Recombinant Human Complement factor H-related protein 4(CFHR4),Yeast
  • 货号：
    CSB-YP838769HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Complement factor H-related protein 4(CFHR4),Yeast
  • 货号：
    CSB-EP838769HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Complement factor H-related protein 4(CFHR4),Yeast
  • 货号：
    CSB-EP838769HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Complement factor H-related protein 4(CFHR4),Yeast
  • 货号：
    CSB-BP838769HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Complement factor H-related protein 4(CFHR4),Yeast
  • 货号：
    CSB-MP838769HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CFHR4
  • Uniprot No.：
  • 别名：
    CFHR4; CFHL4; FHR4Complement factor H-related protein 4; FHR-4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-331
  • 氨基酸序列
    E VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ SYSYYCDQNF VTPSGSYWDY IHCTQDGWSP TVPCLRTCSK SDIEIENGFI SESSSIYILN KEIQYKCKPG YATADGNSSG SITCLQNGWS AQPICIKFCD MPVFENSRAK SNGMRFKLHD TLDYECYDGY EISYGNTTGS IVCGEDGWSH FPTCYNSSEK CGPPPPISNG DTTSFLLKVY VPQSRVEYQC QSYYELQGSN YVTCSNGEWS EPPRCIHPCI ITEENMNKNN IQLKGKSDIK YYAKTGDTIE FMCKLGYNAN TSVLSFQAVC REGIVEYPRC E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
  • 基因功能参考文献：
    1. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR4] PMID: 27196323
    2. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease. PMID: 25979655
    3. Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein PMID: 22518841
    4. Systemic lupus erythematosus were detected in European Americans and African Americans, which could be attributed to an intronic complement regulator factor H (CFH) single nucleotide polymorphism (SNP) and an intergenic SNP between CFHR1 and CFHR4. PMID: 21637784
    5. These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP and suggest a role for CFHR4 in enhancing opsonization via CRP binding. PMID: 20042240
    6. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. PMID: 19861685
    7. FHR-4A is a new Factor H-related protein with a unique domain composition, that is an internal duplication of four CCP domains FHR-4A provides the first evidence for alternative splicing among Factor H-related genes. PMID: 15562282
    8. These data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells. PMID: 19084272

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    HGNC: 16979

    OMIM: 605337

    KEGG: hsa:10877

    STRING: 9606.ENSP00000356386

    UniGene: Hs.710100