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  4. Recombinant Human Chordin-like protein 1 (CHRDL1)

Recombinant Human Chordin-like protein 1 (CHRDL1)

  • 中文名称：
    Recombinant Human Chordin-like protein 1(CHRDL1),Yeast
  • 货号：
    CSB-YP866283HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Chordin-like protein 1(CHRDL1),Yeast
  • 货号：
    CSB-EP866283HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Chordin-like protein 1(CHRDL1),Yeast
  • 货号：
    CSB-EP866283HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Chordin-like protein 1(CHRDL1),Yeast
  • 货号：
    CSB-BP866283HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Chordin-like protein 1(CHRDL1),Yeast
  • 货号：
    CSB-MP866283HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CHRDL1
  • Uniprot No.：
  • 别名：
    CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-450
  • 氨基酸序列
    EQVKHSETY CMFQDKKYRV GERWHPYLEP YGLVYCVNCI CSENGNVLCS RVRCPNVHCL SPVHIPHLCC PRCPDSLPPV NNKVTSKSCE YNGTTYQHGE LFVAEGLFQN RQPNQCTQCS CSEGNVYCGL KTCPKLTCAF PVSVPDSCCR VCRGDGELSW EHSDGDIFRQ PANREARHSY HRSHYDPPPS RQAGGLSRFP GARSHRGALM DSQQASGTIV QIVINNKHKH GQVCVSNGKT YSHGESWHPN LRAFGIVECV LCTCNVTKQE CKKIHCPNRY PCKYPQKIDG KCCKVCPGKK AKELPGQSFD NKGYFCGEET MPVYESVFME DGETTRKIAL ETERPPQVEV HVWTIRKGIL QHFHIEKISK RMFEELPHFK LVTRTTLSQW KIFTEGEAQI SQMCSSRVCR TELEDLVKVL YLERSEKGHC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
  • 基因功能参考文献：
    1. Finally, in vivo experiments confirmed that CHRDL1 acted as a tumor suppressor gene in suppressing tumor growth and metastasis PMID: 28423564
    2. Results show that Chrdl1 expression is upregulated in numerous breast cancer cells following TGF-beta stimulation and demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced migration and invasion. PMID: 26976638
    3. These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4). PMID: 26955889
    4. We provide the initial confirmation that X-linked megalocornea is associated with mutations in the CHRDL1 gene. PMID: 24073597
    5. CHRDL1 plays a key role in cornea homeostasis as evidenced by disease causing mutations in X-linked megalocornea. PMID: 25712132
    6. The detection of mutations in the CHRDL1 gene is useful for differential diagnosis with different forms of megalocornea. PMID: 26020825
    7. Novel CHRDL1 mutations in ten families with X-linked megalocornea, are reported. PMID: 25093588
    8. CHRDL1 is expressed in the developing human cornea and anterior segment in addition to the retina. PMID: 22284829
    9. Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis. PMID: 18587495
    10. reports the cloning of chick ventroptin and its importance in topographic retinotectal projection PMID: 11441185

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  • 相关疾病：
    Megalocornea 1, X-linked (MGC1)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
  • 数据库链接：

    HGNC: 29861

    OMIM: 300350

    KEGG: hsa:91851

    STRING: 9606.ENSP00000361112

    UniGene: Hs.496587