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  4. Recombinant Human Cell division cycle-associated 7-like protein (CDCA7L)

Recombinant Human Cell division cycle-associated 7-like protein (CDCA7L)

  • 中文名称：
    Recombinant Human Cell division cycle-associated 7-like protein(CDCA7L),Yeast
  • 货号：
    CSB-YP850301HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cell division cycle-associated 7-like protein(CDCA7L),Yeast
  • 货号：
    CSB-EP850301HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cell division cycle-associated 7-like protein(CDCA7L),Yeast
  • 货号：
    CSB-EP850301HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cell division cycle-associated 7-like protein(CDCA7L),Yeast
  • 货号：
    CSB-BP850301HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cell division cycle-associated 7-like protein(CDCA7L),Yeast
  • 货号：
    CSB-MP850301HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CDCA7L
  • Uniprot No.：
  • 别名：
    c Myc Interacting protein JPO2; CDA7L_HUMAN; Cdca7l; Cell division cycle-associated 7-like protein; DKFZp762L0311; HR1; JPO2; Protein JPO2; R1; RAM2; Transcription factor RAM2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-454
  • 氨基酸序列
    MELATRYQIP KEVADIFNAP SDDEEFVGFR DDVPMETLSS EESCDSFDSL ESGKQQDVRF HSKYFTEELR RIFIEDTDSE TEDFAGFTQS DLNGKTNPEV MVVESDLSDD GKASLVSEEE EDEEEDKATP RRSRSRRSSI GLRVAFQFPT KKLANKPDKN SSSEQLFSSA RLQNEKKTIL ERKKDCRQVI QREDSTSESE DDSRDESQES SDALLKRTMN IKENKAMLAQ LLAELNSMPD FFPVRTPTSA SRKKTVRRAF SEGQITRRMN PTRSARPPEK FALENFTVSA AKFAEEFYSF RRRKTIGGKC REYRRRHRIS SFRPVEDITE EDLENVAITV RDKIYDKVLG NTCHQCRQKT IDTKTVCRNQ GCCGVRGQFC GPCLRNRYGE DVRSALLDPD WVCPPCRGIC NCSYCRKRDG RCATGILIHL AKFYGYDNVK EYLESLQKEL VEDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
  • 基因功能参考文献：
    1. Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis. PMID: 27882933
    2. We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma PMID: 27013196
    3. common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN PMID: 26245978
    4. The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC. PMID: 25480495
    5. Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75. PMID: 24634210
    6. CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression. PMID: 24141559
    7. Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A protein levels within the major depressive disorder groups compared with controls. PMID: 21654740
    8. monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 PMID: 16728402
    9. demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways PMID: 16829576
    10. Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 PMID: 17669426

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
  • 组织特异性：
    Ubiquitous. Overexpressed in medulloblastoma.
  • 数据库链接：

    HGNC: 30777

    OMIM: 609685

    KEGG: hsa:55536

    STRING: 9606.ENSP00000383986

    UniGene: Hs.744069