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  4. Recombinant Human Calpain-10 (CAPN10)

Recombinant Human Calpain-10 (CAPN10)

  • 中文名称：
    Recombinant Human Calpain-10(CAPN10),Yeast
  • 货号：
    CSB-YP864027HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Calpain-10(CAPN10),Yeast
  • 货号：
    CSB-EP864027HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Calpain-10(CAPN10),Yeast
  • 货号：
    CSB-EP864027HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Calpain-10(CAPN10),Yeast
  • 货号：
    CSB-BP864027HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Calpain-10(CAPN10),Yeast
  • 货号：
    CSB-MP864027HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CAPN10
  • Uniprot No.：
  • 别名：
    Calcium activated neutral protease ; Calcium activated neutral proteinase 10; Calcium-activated neutral proteinase 10; calpain like protease CAPN10; Calpain-10; Calpain10; CAN10_HUMAN; CANP 10; CANP10; CAPN 10; CAPN10; EC 3.4.22.; KIAA1845; NIDDM1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-672
  • 氨基酸序列
    MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS IHSQEMLGQF LQEVSIMAVM KT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
  • 基因功能参考文献：
    1. This study provides evidence that SNP43 (G/A) in the CAPN10 gene increases the risk of cognitive impairment in cerebral small vessel disease patients. PMID: 30014550
    2. The 3R/3R genotype of the indel-19 variant of the CAPN-10 gene influenced increased glucose levels in these Mexican women with gestational diabetes mellitus. PMID: 29506634
    3. TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with gestational diabetes risks. [meta-analysis] PMID: 28277135
    4. association between SNP 63 of CAPN10 and gestational diabetes mellitus is only significant in the heterozygous model PMID: 27324783
    5. There were significant differences between the type 2 diabetes mellitus patients and controls in the risk allele distributions of rs3792267 (CAPN10) (P = 0.002), rs1501299 (APM1) (P = 0.017), and rs3760776 (FUT6) (P = 0.031). PMID: 27374856
    6. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS, IRS2, PPAR-G and CAPN10 failed to show any association with PCOS in our studied population. PMID: 28360393
    7. These findings indicate that the Calpain-10 SNP 43 may be related to obstructive sleep apnea/hypopnea syndrome with ischemic stroke, with SNP 43 GG genotype as a risk factor for obstructive sleep apnea/hypopnea with ischemic stroke PMID: 28422847
    8. Subjects with the GG genotype of the rs2975762 variant of the CAPN10 gene were better responders to dietary intervention, showing increased HDL-C concentrations from the first month of treatment PMID: 25238846
    9. due to its association with androgen excess in phenotype A, CAPN 10 gene polymorphism UCSNP-43 could be used as a genetic marker for CVD in young PCOS women. PMID: 26376770
    10. genetic association studies in Asian populations: Data suggest that an SNP in CAPN10 (SNP43 G>A, rs3792267) is associated with type 2 diabetes in Asian populations, especially in Chinese populations. [META-ANALYSIS] PMID: 25382134
    11. SNP-63 and indel-19 variant of the CAPN10 gene do not represent a risk factor for polycystic ovary syndrome in Mexican women of reproductive age. PMID: 25982606
    12. Data indicate no association between calpain 10 (CAPN10) polymorphisms and type 2 diabetes mellitus. PMID: 25867367
    13. 121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in the Calpain-10 gene are associated with the development of type 2 diabetes in Turkish patients. PMID: 24802731
    14. Different mutations in CAPN10 have already been found in three independent Iranian families PMID: 25773692
    15. This work confirms the association of CAPN10 gene with metabolic components in PCOS and highlights the role of haplotypes as strong and efficient genetic markers. PMID: 24993116
    16. The present study provides the first observation of an association between a variant in CAPN10 gene and the response to metformin therapy in patients with type 2 diabetes PMID: 25327507
    17. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight in Colombian patients 10-18 years of age even those with physically active lifestyles. PMID: 25504243
    18. SNP-19 in CAPN10 may participate in the development of diabetes mellitus type 2 PMID: 25617558
    19. We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad. PMID: 24612564
    20. results of present meta-analysis indicate an association of T2D with carriers of DD genotype of CAPN10 I/D polymorphism PMID: 24429295
    21. Calpain-10 SNP43 and SNP19 polymorphisms are associated with colorectal cancer. PMID: 24377587
    22. Variations of SNP-43, -63 and Indel-19 of CAPN10 were not associated with an increased risk of developing gestational diabetes mellitus. PMID: 24266779
    23. Calpain 10 shows association between the single nucleotide polymorphism (SNP)-43, but not SNP-19 nor -63, and type 2 diabetes mellitus in the Kurdish ethnic group of West Iran PMID: 24779302
    24. Used homology modelling technique to study the 3D structure of calpain-10 from Homo sapiens and its interaction with the protease inhibitor SNJ-1715. PMID: 24034724
    25. Polymorphisms in the Calpain-10 gene may be risk factors for PCOS, especially among Asian populations.[meta-analysis] PMID: 23994294
    26. Significant association of SNP -43 in CAPN10 with the risk of cardiovascular disease coexisting with T2 Diabetes mellitus. PMID: 23021796
    27. GAEC1 regulates the expression of CAPN10 in esophageal squamous cell carcinoma. Calpain 10 expression is a potential prognostic marker. PMID: 23687414
    28. We identified reduced Calpain-10 expression in a pediatric population with overweight and obese phenotypes. PMID: 23262350
    29. analysis of copy number variation of CAPN10 in Thais with type 2 diabetes by multiplex PCR and denaturing high performance liquid chromatography PMID: 22796443
    30. CAPN10 SNPs and haplotypes are associated with polycystic ovary syndrome among South Indian Women PMID: 22384174
    31. Studies indicate UCSNP-63 of CAPN 10 gene was significantly associated with polycystic ovary syndrome (PCOS). PMID: 21906115
    32. CAPN-10 gene SNP-56 plays a role in glucose and lipid metabolism in Chinese PCOS patients but does not contribute to the genetic susceptibility of PCOS. PMID: 18683748
    33. CAPN10 SNP-19 is associated with glucose metabolism disorders in pregnant women. PMID: 19570442
    34. This study raises the possibility that the 2111 haplotype of SNPs -44, -43, -19, and -63 may be associated with type 2 diabetes mellitus, although none of these SNPs may be individually associated with diabetes. PMID: 20667559
    35. genetic association studies in a European cohort: CAPN10 SNP (rs2953171) may influence insulin sensitivity by interacting with plasma fatty acid composition in subjects with metabolic syndrome PMID: 21389182
    36. Calpain 10 gene polymorphism is modifying laryngeal cancer risk and mortality in Spanish population. PMID: 20848425
    37. calpain 10 UCSNP-19 polymorphism and haplotype 111 contribute to the risk of type 2 diabetes (T2DM) in Tunisian subjects but no significant association between calpain 10 diplotypes and T2DM was demonstrated PMID: 20570542
    38. variation in CAPN10 may be associated with increased risk of pancreatic cancer among smokers PMID: 20178008
    39. SNP-44 polymorphism of the calpain-10 gene has a significant association with T2DM patients in the Gaza strip PMID: 20881413
    40. Meta-analysis and uncategorized study of gene-disease association. (HuGE Navigator) PMID: 20923526
    41. Certain three window haplotypes may confer increased risk for T2DM and others may be protective suggesting that genetic variation in CAPN10 gene may be one factor involved in the aetiology of T2DM in Irish adults. PMID: 20119856
    42. CAPN10 gene may play an important role in the pathogenesis of impaired fasting glucose or impaired glucose tolerance in patients with esential hypertension. PMID: 20406624
    43. the most common haplotype 121 (OR = 0.70 95% CI: 0.50-0.99) was associated with a reduced risk for type 2 diabetes in East Indian population PMID: 20368234
    44. Patients' higher body mass index and SNP-63 minor T allele carrier status were identified as independent posttransplant diabetes mellitus risk factors. PMID: 19752882
    45. CAPN10 UCSNP-19 variant, and the 111 haplotype contribute to the risk of T2D in Tunisian subjects; no significant associations between CAPN10 diplotypes and T2D were demonstrated for Tunisians. PMID: 20470430
    46. prostate cancer was positively associated with the CAPN10 rs3792267 G allele PMID: 20142250
    47. The association with T2DM in different races was evaluated. SNP43-G allele, G/G genotype, 111/221 were risk factors to Mongoloid race. And SNP-C allele, 111/111 haplotype combination were risk factors to Caucasoid race, and SNP44-C allele to Hybrid race. PMID: 20193213
    48. calpain-10 mRNA was elevated by 64% in pancreatic islets from patients with T2D compared with non-diabetic donors. Moreover, the calpain-10 expression correlated positively with arginine-stimulated insulin release in islets from non-diabetic donors PMID: 19688040
    49. type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association PMID: 11704924
    50. The variation of calpain-10 gene has impact on the variation of clinical metabolic parameter levels related to type 2 diabetes mellitus. PMID: 11774208

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  • 相关疾病：
    Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1)
  • 蛋白家族：
    Peptidase C2 family
  • 组织特异性：
    Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
  • 数据库链接：

    HGNC: 1477

    OMIM: 601283

    KEGG: hsa:11132

    STRING: 9606.ENSP00000375844

    UniGene: Hs.728234