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  4. Recombinant Human Calcineurin subunit B type 2 (PPP3R2)

Recombinant Human Calcineurin subunit B type 2 (PPP3R2)

  • 中文名称：
    人PPP3R2重组蛋白
  • 货号：
    CSB-YP856978HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPP3R2重组蛋白
  • 货号：
    CSB-EP856978HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPP3R2重组蛋白
  • 货号：
    CSB-BP856978HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPP3R2重组蛋白
  • 货号：
    CSB-MP856978HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Calcineurin B like protein; Calcineurin B type II (19kDa); Calcineurin B type II; Calcineurin B-like protein; Calcineurin BII; Calcineurin subunit B isoform 2; Calcineurin subunit B type 2; CANB2_HUMAN; CBLP; CBLP like; CNBII; PPP3R1-like; Ppp3r2; PPP3RL; Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 (formerly 2B) regulatory subunit B (19kD) beta isoform (calcineurin B type II); Protein phosphatase 3 (formerly 2B) regulatory subunit B beta isoform; Protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; beta isoform (calcineurin B; type II); Protein phosphatase 3 regulatory subunit B (19kD) beta isoform (calcineurin B type II); Protein phosphatase 3 regulatory subunit B (calcineurin B) like; Protein phosphatase 3 regulatory subunit B beta; Protein phosphatase 3 regulatory subunit B beta isoform
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-170
  • 氨基酸序列
    GNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF EEFSAVVRDL EIHKKLVLIV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
  • 基因功能参考文献：
    1. PPP3RL gene localizes to human chromosome 9q22 and transcripts of PPP3RL gene are specifically expressed in the testis. PMID: 15865209
    2. cyclosporin and tacrolimus exert significantly different effects on calcineurin activity in renal transplant patients with stable, well-functioning grafts PMID: 16961774
    3. calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation PMID: 17324936
    4. Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues. PMID: 17531200
    5. Data suggest that calcineurin may regulate the kinase activity of CDK4 in a cell cycle-dependent manner and may be an important component of the negative regulation of CDK4. PMID: 17892862

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  • 蛋白家族：
    Calcineurin regulatory subunit family
  • 组织特异性：
    Testis-specific.
  • 数据库链接：

    HGNC: 9318

    OMIM: 613821

    KEGG: hsa:5535

    STRING: 9606.ENSP00000363939

    UniGene: Hs.151167