Recombinant Human CREB3 regulatory factor (CREBRF)
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中文名称:Recombinant Human CREB3 regulatory factor(CREBRF),Yeast
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货号:CSB-YP815547HU
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规格:
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来源:Yeast
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其他:
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中文名称:Recombinant Human CREB3 regulatory factor(CREBRF),Yeast
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货号:CSB-EP815547HU
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规格:
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来源:E.coli
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其他:
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中文名称:Recombinant Human CREB3 regulatory factor(CREBRF),Yeast
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货号:CSB-EP815547HU-B
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规格:
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来源:E.coli
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共轭:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名称:Recombinant Human CREB3 regulatory factor(CREBRF),Yeast
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货号:CSB-BP815547HU
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规格:
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来源:Baculovirus
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其他:
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中文名称:Recombinant Human CREB3 regulatory factor(CREBRF),Yeast
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货号:CSB-MP815547HU
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规格:
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来源:Mammalian cell
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其他:
产品详情
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纯度:>85% (SDS-PAGE)
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基因名:CREBRF
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Uniprot No.:
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别名:adult retina protein ; C5orf41; Chromosome 5 Open Reading Frame 41; CREB3 regulatory factor; CREBRF; CRERF_HUMAN; Hypothetical protein; LRF; Luman recruitment factor
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种属:Homo sapiens (Human)
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蛋白长度:full length protein
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表达区域:1-639
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氨基酸序列MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN YQQNPRDNFL SLEDCKDIEN LESFTDVLDN EGALTSNWEQ WDTYCEDLTK YTKLTSCDIW GTKEVDYLGL DDFSSPYQDE EVISKTPTLA QLNSEDSQSV SDSLYYPDSL FSVKQNPLPS SFPGKKITSR AAAPVCSSKT LQAEVPLSDC VQKASKPTSS TQIMVKTNMY HNEKVNFHVE CKDYVKKAKV KINPVQQSRP LLSQIHTDAA KENTCYCGAV AKRQEKKGME PLQGHATPAL PFKETQELLL SPLPQEGPGS LAAGESSSLS ASTSVSDSSQ KKEEHNYSLF VSDNLGEQPT KCSPEEDEED EEDVDDEDHD EGFGSEHELS ENEEEEEEEE DYEDDKDDDI SDTFSEPGYE NDSVEDLKEV TSISSRKRGK RRYFWEYSEQ LTPSQQERML RPSEWNRDTL PSNMYQKNGL HHGKYAVKKS RRTDVEDLTP NPKKLLQIGN ELRKLNKVIS DLTPVSELPL TARPRSRKEK NKLASRACRL KKKAQYEANK VKLWGLNTEY DNLLFVINSI KQEIVNRVQN PRDERGPNMG QKLEILIKDT LGLPVAGQTS EFVNQVLEKT AEGNPTGGLV GLRIPTSKV
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蛋白标签:Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
产品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
复溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
靶点详情
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功能:Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
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基因功能参考文献:
- The presence of each additional CREBRF rs373863828 A allele is associated with increased BMI yet reduced odds of type 2 diabetes in adults of Maori and Pacific (Polynesian) ancestry living in Aotearoa/New Zealand. PMID: 29721634
- We found that CREBRF and TRIM2 mRNA were significantly upregulated by rHDL, particularly in response to its phospholipid component 1-palmitoyl-2-linoleoyl-phosphatidylcholine, however, protein expression was not significantly altered. PMID: 29958463
- The rs373863828-A allele (a missense variant of the CREBRF gene) may not directly affect the level of serum HDL-cholesterol independent of BMI. PMID: 29877158
- CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway. PMID: 29729692
- The rs373863828-A allele was not found in both AN-speaking and non-AN-speaking Melanesians living in Papua New Guinea. Our results suggest that rs373863828-A of CREBRF, a promising thrifty variant, arose in recent ancestors of AN-speaking Polynesians. PMID: 28405013
- Missense Mutation in CREBRF gene is associated with obesity. PMID: 27455349
- Findings provide new insight into the molecular mechanisms underlying hypoxia-induced glioblastoma cell autophagy and indicate that the hypoxia/CREBRF/CREB3/ATG5 pathway plays a central role in malignant glioma progression. PMID: 27278737
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亚细胞定位:Nucleus. Note=Colocalizes with CREB3 in nuclear foci.
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蛋白家族:BZIP family, CREBRF subfamily
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数据库链接:
HGNC: 24050
KEGG: hsa:153222
STRING: 9606.ENSP00000296953
UniGene: Hs.484195
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