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  4. Recombinant Human Bone morphogenetic protein 1 (BMP1)

Recombinant Human Bone morphogenetic protein 1 (BMP1)

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  • 中文名称：
    Recombinant Human Bone morphogenetic protein 1(BMP1)
  • 货号：
    CSB-EP002733HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    BMP1
  • Uniprot No.：
  • 别名：
    BMP 1; BMP-1; BMP1; BMP1_HUMAN; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; OI13; PCOLC; PCP; PCP2; Procollagen C endopeptidase; Procollagen C proteinase; Procollagen C-proteinase; TLD; Tolloid; Drosophila; homolog of
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    102.0kDa
  • 表达区域：
    121-986aa
  • 氨基酸序列
    AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; Plays an important role in bone repair by acting as a coactivator of BMP7.
  • 基因功能参考文献：
    1. investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of coronary heart disease. PMID: 30062502
    2. Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway. PMID: 28944874
    3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
    4. BMP1 c.941G>A (p.(R314H)) variant was identified in the family with Chiari malformation type 1. PMID: 28513615
    5. Results indicate the significance of follistatin-like protein 1 (FSTL1) in driving oncogenesis and metastasis in esophageal squamous cell carcinoma (ESCC) by coordinating NF-kappa B (NFkappaB) and bone morphogenetic proteins (BMP) pathway control. PMID: 28883005
    6. Given the association of BMP1-related Osteogenesis Imperfecta (OI) with very high bone material density, concerns remain whether anti-resorptive therapy is indicated in this ultra-rare form of OI PMID: 27576954
    7. Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity. PMID: 27782377
    8. a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications. PMID: 26944735
    9. BMP-1 accelerates the connective tissue growth factor production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 which potentially enhances bone-like reparative dentin formation. PMID: 25944709
    10. Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways. PMID: 26592459
    11. study thus highlights the severe and progressive nature of BMP1-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM organization. PMID: 25656619
    12. Data indicate that BMP-1 can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review] PMID: 25701650
    13. Two novel variants in the BMP1 gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta. PMID: 25402547
    14. Frequent bone fracture in children is cause by BMP1-1 deficiency. PMID: 25214535
    15. mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency PMID: 25158199
    16. High BMP1 expression is associated with type-1 diabetes. PMID: 24984282
    17. Loss of bone morphogenetic protein is associated with prostate cancer. PMID: 24042462
    18. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1 PMID: 23584484
    19. Sequence analysis of BMP1 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 PMID: 23640157
    20. Controlling inhibition of bone morphogenetic protein (BMP1) modulates the number of SOX1 expressing cells, whereas PAX6, another neural precursor marker, remains the same. PMID: 22860217
    21. Excluding anterior cervical fusions, there are no significant differences between spinal fusion procedures with and without BMP-associated overall complications. PMID: 21897187
    22. The molecular and cellular bases of BMP1-dependent osteogenesis were defined. The importance of BMP1 for bone formation and stability were shown in humans and zebrafish. PMID: 22482805
    23. We conclude that BMP1 is an additional gene mutated in autosomal recessive osteogenesis imperfecta (AR-OI). PMID: 22052668
    24. High expression of BMP pathway genes are associated with atypical teratoid/rhabdoid tumors. PMID: 21946044
    25. Disruption of BMPR1A-mediated BMP1 signalling during the narrow window of early embryogenesis may interfere with normal VBW formation, causing omphalocele phenotype in the Cd chick model. PMID: 21258932
    26. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
    27. BMP1-3 is a novel systemic regulator of bone repair. PMID: 21453682
    28. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. PMID: 21415150
    29. Three isoforms of BMP1 ranging from the shortest BMP1-5 to the longest (mTLD, inefficient at processing procollagen in vitro) were all shown to be capable of removing the highly conserved propeptides from both proDCN. PMID: 20026052
    30. Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
    31. bone morphogenetic protein-1 (BMP-1), which exhibits procollagen C-proteinase activity, cleaves the C-terminal propeptide from human procollagen VII PMID: 11986329
    32. Post-translational modification is required for secretion and stability of the protein. PMID: 12218058
    33. the minimal domain structure for PCP activity is considerably shorter than expected and comprises the metalloproteinase domain and the CUB1 and CUB2 domains of BMP-1 PMID: 12637537
    34. Pro-BMP-1 is cleaved in the trans-Golgi network PMID: 12637569
    35. Dermal wound healing in red Duroc pigs show unique mRNA expression of HSP47,BMP-1,TIMP1-3 and hypercontracted,hyperpigmented scars. PMID: 15225209
    36. cleaves LG3 from recombinant endorepellin at the physiologically relevant site and cleaves LG3 from endogenous perlecan in cultured mouse and human cells PMID: 15591058
    37. chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
    38. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
    39. bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin PMID: 17071617
    40. the BMP1 prodomain specifically binds and regulates signaling by BMP2 and BMP4 PMID: 17255107
    41. By mutating residues flanking the cleavage site of collagen type V alpha 1, we showed that the aspartate residue at position P2' is essential for BMP-1 activity. PMID: 17407447
    42. data support the concept that the C-terminal domains of BMP1 are important for substrate recognition and for controlling and restricting its proteolytic activity via exosite binding PMID: 17516847
    43. BMP1 processes PRL to a 17-kDa anti-angiogenic factor. PMID: 17548836
    44. vascular Bmp Msx2 Wnt signaling and oxidative stress have roles in arterial calcification [review] PMID: 18056036
    45. Expression of BMP1, BMP6, BMP7, and BMP-receptor 2 was significantly increased in advanced stages of myelofibrosis compared and enhanced levels of BMP6 expression were already evident in prefibrotic stages of primary myelofibrosis. PMID: 18349123
    46. The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported. PMID: 18824173
    47. BMP-1 expression was significantly higher in thyroid tumors with psammoma bodies or with stromal calcification. PMID: 19305382
    48. Regulation of alternative splicing of mRNA for procollagen C-endopeptidase in leiomyomas and myometrium depends mainly on the hormonal status of women PMID: 19323056
    49. FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases. PMID: 19617627

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  • 相关疾病：
    Osteogenesis imperfecta 13 (OI13)
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted.; [Isoform BMP1-3]: Secreted.
  • 蛋白家族：
    Peptidase M12A family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 1067

    OMIM: 112264

    KEGG: hsa:649

    STRING: 9606.ENSP00000305714

    UniGene: Hs.1274