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  4. Recombinant Human Beta-secretase 2 (BACE2), partial

Recombinant Human Beta-secretase 2 (BACE2), partial

  • 中文名称：
    Recombinant Human Beta-secretase 2(BACE2),partial,Yeast
  • 货号：
    CSB-YP896746HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Beta-secretase 2(BACE2),partial,Yeast
  • 货号：
    CSB-EP896746HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Beta-secretase 2(BACE2),partial,Yeast
  • 货号：
    CSB-EP896746HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Beta-secretase 2(BACE2),partial,Yeast
  • 货号：
    CSB-BP896746HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Beta-secretase 2(BACE2),partial,Yeast
  • 货号：
    CSB-MP896746HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BACE2
  • Uniprot No.：
  • 别名：
    ALP 56; ALP56; Asp 1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
  • 基因功能参考文献：
    1. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    2. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. PMID: 23903356
    3. BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis. PMID: 23754390
    4. BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels. PMID: 22986058
    5. The BACE2 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    6. All these data point to a role for BACE2 in the IRbeta trafficking and insulin signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function. PMID: 20943756
    7. Trransgenic BACE2 mice show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in the locus coeruleus. PMID: 19840121
    8. BACE has a loose substrate specificity and that the substrate recognition site in BACE extends over several amino acids PMID: 11741910
    9. Specificity and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity PMID: 12093293
    10. the enzymatic properties of BACE2 were analyzed, including substrate specificity and pH range PMID: 12423367
    11. A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer. ALP56 may be a useful target molecule in breast cancer treatment. PMID: 12611455
    12. antagonistic effect with beta-site amyloid precursor protein-cleaving enzyme 1 on beta-amyloid peptide production in cells PMID: 12801932
    13. Analysis revealed a 2.6-fold increase in BACE-2 mRNA levels in Down syndrome brains compared to the control group; increased secretion of BACE-2 by cultured fibroblasts and neural stem cells from Down syndrome patients was noted PMID: 12895444
    14. Chromosome 21 BACE2 haplotype associates with Alzheimer's disease PMID: 16023140
    15. the crystal structure of mature BACE2 in complex with a hydroxyethylamine transition-state mimetic inhibitor at 3.1 angstroms resolution was presented. PMID: 16305800
    16. Data characterize the human beta-secretase 2 (BACE2) 5'-flanking region. PMID: 16757812
    17. BACE2is not involved in the Alzheimer dissease(AD)pathogenesis of Down syndrome (DS) patients; instead, therapeutic interventions that potentiate BACE2 may prevent AD pathogenesis. PMID: 16816112
    18. The expression levels of BACE2 was comparable between DS and controls in fetal brain and in adult brain. PMID: 18163181
    19. study found no association between three BACE2 polymorphisms and sporadic Alzheimer's disease in the Chinese Han population even after statistical adjustment for age, gender and APOE epsilon 4 status PMID: 19124009

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.
  • 蛋白家族：
    Peptidase A1 family
  • 组织特异性：
    Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed
  • 数据库链接：

    HGNC: 934

    OMIM: 605668

    KEGG: hsa:25825

    STRING: 9606.ENSP00000332979

    UniGene: Hs.43047