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  4. Recombinant Human Annexin A8 (ANXA8)

Recombinant Human Annexin A8 (ANXA8)

  • 中文名称：
    Recombinant Human Annexin A8(ANXA8),Yeast
  • 货号：
    CSB-YP001849HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Annexin A8(ANXA8),Yeast
  • 货号：
    CSB-EP001849HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Annexin A8(ANXA8),Yeast
  • 货号：
    CSB-EP001849HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Annexin A8(ANXA8),Yeast
  • 货号：
    CSB-BP001849HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Annexin A8(ANXA8),Yeast
  • 货号：
    CSB-MP001849HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ANXA8
  • Uniprot No.：
  • 别名：
    Annexin A8; Annexin VIII; Annexin-8; ANX8; Anxa8; ANXA8_HUMAN; VAC beta; VAC-beta; Vascular anticoagulant beta; Vascular anticoagulant-beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
  • 基因功能参考文献：
    1. These findings identify Anxa8 as a regulator of late endosomes/lysosomes cholesterol balance. PMID: 29306076
    2. We conclude that AnxA8 affects CD63/VEGFR2/beta1 integrin complex formation, leading to hyperactivation of the VEGF-A signal transduction pathway, and severely disturbed VEGF-A-driven angiogenic sprouting. PMID: 28060564
    3. Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis PMID: 27451994
    4. Increased annexin A8 expression is associated with poor prognosis in early-stage pancreatic cancer. PMID: 25268673
    5. High ANXA8 gene expression is associated with lymph node metastasis in oral squamous cell carcinoma. PMID: 26700817
    6. Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. PMID: 24769558
    7. High ANXA8 expression is associated with pancreatic cancer. PMID: 23001853
    8. Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring. PMID: 21344395
    9. Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer PMID: 16203777
    10. binds Ca2+-dependently and with high specificity to phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) and is also capable of interacting with F-actin PMID: 16638567
    11. Data suggest that defective transport through the late endocytic pathway and imbalanced signaling in the absence of annexin A8 results from disturbed association of late endosomal membranes with actin and impaired endosome motility. PMID: 18923148

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  • 蛋白家族：
    Annexin family
  • 数据库链接：

    HGNC: 546

    OMIM: 602396

    KEGG: hsa:653145

    STRING: 9606.ENSP00000341674

    UniGene: Hs.535306