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  4. Recombinant Human Ankyrin repeat domain-containing protein 2 (ANKRD2)

Recombinant Human Ankyrin repeat domain-containing protein 2 (ANKRD2)

  • 中文名称：
    Recombinant Human Ankyrin repeat domain-containing protein 2(ANKRD2),Yeast
  • 货号：
    CSB-YP875635HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat domain-containing protein 2(ANKRD2),Yeast
  • 货号：
    CSB-EP875635HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat domain-containing protein 2(ANKRD2),Yeast
  • 货号：
    CSB-EP875635HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat domain-containing protein 2(ANKRD2),Yeast
  • 货号：
    CSB-BP875635HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin repeat domain-containing protein 2(ANKRD2),Yeast
  • 货号：
    CSB-MP875635HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ANKRD2
  • Uniprot No.：
  • 别名：
    ANKRD2; ARPPAnkyrin repeat domain-containing protein 2; Skeletal muscle ankyrin repeat protein; hArpp
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-360
  • 氨基酸序列
    MAKAPSWAGV GALAYKAPEA LWPAEAVMDG TMEDSEAVQR ATALIEQRLA QEEENEKLRG DARQKLPMDL LVLEDEKHHG AQSAALQKVK GQERVRKTSL DLRREIIDVG GIQNLIELRK KRKQKKRDAL AASHEPPPEP EEITGPVDEE TFLKAAVEGK MKVIEKFLAD GGSADTCDQF RRTALHRASL EGHMEILEKL LDNGATVDFQ DRLDCTAMHW ACRGGHLEVV KLLQSHGADT NVRDKLLSTP LHVAVRTGQV EIVEHFLSLG LEINARDREG DTALHDAVRL NRYKIIKLLL LHGADMMTKN LAGKTPTDLV QLWQADTRHA LEHPEPGAEH NGLEGPNDSG RETPQPVPAQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
  • 基因功能参考文献：
    1. The results set the stage for investigation of the specific functions and interactions of the Ankrd2 isoforms in healthy and diseased human striated muscles. PMID: 27393496
    2. The Ankrd2 was found to be expressed in both the cytoplasm and nucleus, independently from maturation status of cardiomyocytes. PMID: 25585647
    3. Report structure activity relationships for ANKRD2. PMID: 25125175
    4. Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kappaB repressor subunit p50. PMID: 24434510
    5. The orthologs of ANKRD2 in mouse and rat, which are also titin binding proteins, are stretch-response genes associated with slow muscle function and these proteins are part of a separate mechanotransduction system to the one that regulates muscle mass. PMID: 15677738
    6. Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers. PMID: 22185618
    7. Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes PMID: 22016770
    8. Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation PMID: 21737686
    9. These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis. PMID: 12679596
    10. Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation PMID: 15136035
    11. Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma PMID: 16021567
    12. ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma but not in chromophobe renal cell carcinomas. PMID: 17206105

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
  • 组织特异性：
    Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
  • 数据库链接：

    HGNC: 495

    OMIM: 610734

    KEGG: hsa:26287

    STRING: 9606.ENSP00000306163

    UniGene: Hs.73708