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  4. Recombinant Human Alpha-adducin (ADD1)

Recombinant Human Alpha-adducin (ADD1)

  • 中文名称：
    Recombinant Human Alpha-adducin(ADD1),Yeast
  • 货号：
    CSB-YP001348HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Alpha-adducin(ADD1),Yeast
  • 货号：
    CSB-EP001348HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Alpha-adducin(ADD1),Yeast
  • 货号：
    CSB-EP001348HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Alpha-adducin(ADD1),Yeast
  • 货号：
    CSB-BP001348HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Alpha-adducin(ADD1),Yeast
  • 货号：
    CSB-MP001348HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ADD1
  • Uniprot No.：
  • 别名：
    ADD A; ADD1; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; MGC3339; MGC44427; OTTHUMP00000151163; OTTHUMP00000151164; OTTHUMP00000151165; OTTHUMP00000218664; OTTHUMP00000218665
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-737
  • 氨基酸序列
    MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK KFRTPSFLKK SKKKSDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
  • 基因功能参考文献：
    1. alpha-adducing SNPs were not associated with bone density among lead workers. PMID: 29028685
    2. These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders. PMID: 28686109
    3. The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island. PMID: 29049185
    4. ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis PMID: 26279304
    5. ADD1 rs4963 polymorphism showed an increased hypertension risk. PMID: 28040068
    6. This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus. PMID: 27340988
    7. study shows that the a-adducin G460T polymorphism is associated with essential hypertension PMID: 27349000
    8. Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC) suggesting an association between ADD1 and CRC risk. PMID: 25816007
    9. The T allele of ADD1 is associated with essential hypertension in Asians. PMID: 26042478
    10. study of potential effects of interaction between DNA methylation of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation of ADD1 gene promoter have a significant role in modifying EH susceptibility PMID: 25567773
    11. There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism. PMID: 25262176
    12. A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample. PMID: 24718403
    13. When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered. PMID: 25344630
    14. Data indicate that adducin promotes adhesion by regulating desmosomes and is part of a protective pathway in pemphigus. PMID: 24711455
    15. Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). PMID: 24379415
    16. Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer. PMID: 23985264
    17. concentration of AST was inversely correlated with ADD1 CpG2-5 methylation levels in female controls. These observations may bring new hints to elaborate the pathogenesis of essential hypertension PMID: 23691048
    18. study is the first meta-analysis to evaluate the influences of ACE and ADD1 polymorphisms on blood pressure responses to hydrochlorothiazide to combine the inconsistent results of previous studies PMID: 23863317
    19. the rs4963 polymorphism within ADD1 gene is associated with essential hypertension in the Chinese population PMID: 23509723
    20. role of ADD1 gene polymorphism in hypertension PMID: 22810272
    21. there was no association of ACE and ADD1 gene polymorphism in ischaemic stroke patients PMID: 23540412
    22. genotype and allele frequencies of ACE and ADD1 polymorphisms were compared between patients and controls as well as between ischemic stroke and ICH PMID: 21194526
    23. Hypertension-linked mutation of alpha-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells. PMID: 23284854
    24. Variant genotype combinations of ACE and alphaADDUCIN render the hypertensive patient more vulnerable to recurrent intracerebral hemorrhage PMID: 22198647
    25. genetic variants of the ADD1 and GNB3 genes may have important roles in blood pressure response to the cold pressor test PMID: 22476228
    26. organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin PMID: 22163289
    27. The alpha-adducin Gly460Trp gene polymorphism might modulate renal function decline in the Chinese. PMID: 22677360
    28. Findings support a role for alpha-adducin in memory from nematodes to humans. PMID: 22307086
    29. Data show that alpha-adducin G460W gene polymorphism was linked to essential hypertension (EH) susceptibility. PMID: 22272309
    30. Further studies involving siRNA-mediated knockdowns of spectrin, adducin, or p4.1 revealed that those proteins are needed for efficient docking of enterohaemorrhagic Escherichia coli to host cells. PMID: 22197999
    31. the mechanism for alpha-adducin to shuttle between the cytoplasm and nucleus; a potential role for alpha-adducin in mitosis. PMID: 21736685
    32. In the studied Russian population G460W polymorphism of ADD1 gene can be considered as predisposition gene to hypertension, but its pathological effect is manifested solely under influence of environmental factors. PMID: 22117679
    33. Null association of alpha-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese, but local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese. PMID: 21364877
    34. this meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese. PMID: 21228790
    35. ADD1 variant genotypes were not associated with increased risk but in association with ACE DD genotype resulted in significantly higher risk of PSICH. ACE and ADD1 variant genotypes were associated with nonlobar hematoma. PMID: 21339657
    36. These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling. PMID: 20810786
    37. Alpha-adducin Gly460Trp polymorphism is associated with hypertension. PMID: 20927398
    38. Genetic variration in alpha adducion alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the blood pressure response to exercise. PMID: 20929695
    39. Although the effect of both genetic variants on CIMT was small, this study showed a statistically significant effect of AGTR1 and ADD1 in women PMID: 19620885
    40. The alpha-adducin gene G460W polymorphism was not associated with hypertension in either a case-control study of essential hypertension in Shangha residents or in a meta-analysis of all reports in English. PMID: 19960031
    41. ALPHA AND BETA ADDUCIN POLYMORPHISMS AFFECT DECLINE OF RENAL FUNCTION IN HUMAN IGA NEPHROPATHY. PMID: 19838659
    42. Alpha-adducin Gly460Trp polymorphism is associated with salt-sensitivity. PMID: 20145305
    43. The alpha-adducin G614T polymorphism is associated with the antihypertensive effect of hydrochlorothiazide. PMID: 16266470
    44. effects of environmental, demographic, & genetic factors & their interactions to SBP response to antihypertensive drugs, explained 23% of the total variance. Ethnicity, low sodium intake, & ADD1 614G-->T polymorphism were the only drug-related predictors PMID: 19779464
    45. Role of the alpha-adducin genotype on renal disease progression. PMID: 11918733
    46. interaction between diuretic therapy and the adducin variant on the incidence of myocardial infarction and stroke PMID: 11926892
    47. ADD1 460W allele associated with cardiovascular disease in hypertensive individuals PMID: 12052841
    48. Blood pressure in patients with primary aldosteronism is influenced by alpha-adducin gene polymorphisms. PMID: 12107246
    49. Carotid and femoral intima-media thickness were assessed in subjects genotyped for the presence of the ACE D, aldosterone synthase -344T and alpha-adducin 460Trp alleles. PMID: 12172317
    50. Patients homozygous for the allele of that polymorphism had a LV mass index significantly higher compared with heterozygotes or homozygotes. These subjects also have significantly lower plasma renin activity. PMID: 12195118

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Aldolase class II family, Adducin subfamily
  • 组织特异性：
    Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
  • 数据库链接：

    HGNC: 243

    OMIM: 102680

    KEGG: hsa:118

    STRING: 9606.ENSP00000264758

    UniGene: Hs.183706