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  4. Recombinant Human Alpha- (1,3)-fucosyltransferase, partial

Recombinant Human Alpha- (1,3)-fucosyltransferase, partial

  • 货号：
    CSB-YP325212HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP325212HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP325212HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP325212HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP325212HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FUT4
  • Uniprot No.：
  • 别名：
    3)-fucosyltransferase; Alpha-(1; Alpha-(1,3)-fucosyltransferase; Alpha-3-fucosyltransferase; ELAM-1 ligand fucosyltransferase; ELFT; FCT3A; Fuc-TIV; Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific; Fucosyltransferase 4; Fucosyltransferase IV; FucT-IV; Fut4; FUT4_HUMAN; FUTIV; Galactoside 3-L-fucosyltransferase; Lewis X; LeX; SSEA-1; Stage-Specific Embryonic Antigen 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
  • 基因功能参考文献：
    1. LOX-1(+) CD15(+) polymorphonuclear myeloid-derived suppressor cells were elevated in hepatocellular carcinoma patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress. PMID: 29211299
    2. Low FUT4 expression is associated with Head and Neck Squamous Cell Carcinoma. PMID: 28681122
    3. Data suggest that FUT4 is aberrantly up-regulated in chondrocytes of osteoarthritis articular cartilage; FUT4 is a direct target of MIR26A and MIR26B via NFkappaB signal transduction. (FUT4 = fucosyltransferase-4; MIR26A = microRNA 26a; MIR26B = microRNA 26b) PMID: 29208566
    4. Suggest that lactoferrin and CD15 may serve as specific markers to corroborate a definitive diagnosis in septic cardiomyopathy. PMID: 29809052
    5. s demonstrated that miR-200c targeted and inhibited FUT4 expression, leading to the dysfunction of uterine receptivity. Results also revealed that miR-200c decreased alpha1.3-fucosylation on glycoprotein CD44, which further inactivated Wnt/beta-catenin signaling pathway. PMID: 28914881
    6. The identified colorectal cancer-restricted miR-26a and miR-26b might be implicated in cancer progression via their target gene FUT4. PMID: 28640257
    7. CD15 is a significant prognostic factor in clear cell renal cell carcinoma. PMID: 29036563
    8. FUT4/LeY was critical to the TAMs-mediated EMT; this process might be associated with the up-regulation of Ezrin phosphorylation by FUT4/LeY-mediated fucosylation PMID: 28423676
    9. study enhances the understanding of cancer cell-brain endothelial adhesion and confirms that CD15 plays a crucial role in adhesion PMID: 26472821
    10. CA19-9-Low&Lewis (+) pancreatic cancer is a unique subtype with special biological properties. PMID: 27840089
    11. We observed an upregulation of the transcription factors OCT4 and SOX2 in leukemic cells as compared to normal cells. Conversely, SSEA1 protein was downregulated in leukemic cells. The expression of OCT4, SOX2, and SSEA3 was higher in CD34(+)CD38(-) than in CD34(+)CD38(+) subsets in leukemic cells. PMID: 28718379
    12. is a sensitive and specific marker for intraepithelial and invasive neoplasias of the bile duct PMID: 27442966
    13. The miR-493-5p/FUT4 pathway has therapeutic potential in breast cancer. PMID: 27375041
    14. expression of SSEA-1 immunoreactivity in thyroid neoplasms was associated with more aggressive thyroid carcinomas PMID: 27550342
    15. Data show that after FUT4 down-regulated with siRNA (shFUT4), epithelial-mesenchymal transition (EMT) was obviously inhibited. PMID: 26636541
    16. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions PMID: 26427350
    17. the acquisition of a sialyl moiety by the CD15 antigen may precede the widespread dissemination in Hodgkin lymphoma. PMID: 26418972
    18. MMP-2 and sLe(x) were negative prognostic markers for survival in these head and neck squamous cell carcinoma patients. PMID: 24171785
    19. A subset of choroidal and ciliary body melanomas overexpress the CD15 antigen. PMID: 26290260
    20. Cancer-related CD15/FUT4 overexpression participates in cetuximab or bevacizumab mechanisms of resistance in metastatic colorectal cancer patients. PMID: 26427914
    21. This provides an automated procedure, which shortens the mentally tiring and time-consuming process of microscopic cell counting and thus makes a contribution towards the standardization of tools for diagnosing PJI. PMID: 25869074
    22. Our results indicate that FUT4 and miR-224-3p are crucial regulators of cancer response to chemotherapy, and may serve as therapeutic targets to reverse chemotherapy resistance in breast cancer. PMID: 26701615
    23. Physiologically immature placentas and pathologically immature term placentas were characterized by marked endothelial CD15-immunostaining. Significant loss of CD15-positive endothelium was associated with physiological and accelerated villous maturity. PMID: 25043745
    24. Data suggest that changes in DNA methylation in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4), and (3) matrix metalloproteinase (MMP2 and MMP9) activity. PMID: 25697377
    25. A significant high expression of FUT4 in breast cancer tissues and serum was found compared to controls. PMID: 25776515
    26. This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/beta-catenin signaling pathway PMID: 25896022
    27. level of expression in the macro- and microvasculature reflects the degree of pathological placental villous immaturity PMID: 25149387
    28. The presence of nanog, Oct-4, SSEA-1, and SSEA-4 suggests that periodontal ligament mesenchymal stem cells are less differentiated than bone marrow-derived MSCs, and the frizzled-9/Wnt pathway is important in proliferation and differentiation. PMID: 20458727
    29. The lower expression of FUT4 in HaCaT cells is correlated with the methylation of CpG island in FUT4 promoter. PMID: 25608813
    30. Titration of the monomeric DC-SIGN CRD with Le(X) monitored by 2D NMR revealed significant perturbations of DC-SIGN cross-peak positions in (1)H-(15)N heteronuclear single quantum coherence (HSQC) spectra and identified residues near the binding site. PMID: 25121780
    31. The correlation of sLex overexpression in primary tumors and metastatic lymph nodes, the discrimination among the normal, adenoma, and CRC groups based on sLex expression. PMID: 24425323
    32. FUT4 is a target gene for HSF1 and Sp1 that is required for cell cycle progression in breast cancer epithelial cells.HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells. PMID: 23959823
    33. AQP9 expressing glioma cells were negative for the brain tumor stem cell marker CD15. PMID: 24086629
    34. Results suggest that FUT4-, FUT6- or FUT8-mediated MDR in human HCC is associated with the activation of the PI3K/Akt pathway and the expression of MRP1. PMID: 24232099
    35. The expression of ST3GAL4 leads to SLe(x) antigen expression in gastric cancer cells which in turn induces an increased invasive phenotype through the activation of c-Met PMID: 23799130
    36. Lewis x appeared to be a new, reliable marker that can be used to clearly distinguish invasive hydatidiform moles from choriocarcinomas. PMID: 23681114
    37. TNF increases the expression of alpha2,3-sialyltransferase gene ST3GAL4 PMID: 22691873
    38. High CD15 expression is associated with medulloblastoma. PMID: 22411914
    39. the expression of Lewis Y and FUT4 correlates with endometrial receptivity PMID: 22145955
    40. FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter. PMID: 22287018
    41. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma PMID: 21931765
    42. Resting natural killer (NK) cells that have been coincubated with NK-resistant CD15-positive tumor cells lyse Raji cells and are capable of lysing a variety of NK-resistant tumor cells of different lineages. PMID: 22084431
    43. Data indicate that among MDS cases, CD15+ and CD19+ cell TLs were positively correlated, and PBL TL was was not associated with hTERT genotype. PMID: 21635204
    44. Data show that tumours induced by transformed fibroblasts are hierarchically organized, and the cells that act as CSCs to initiate and maintain tumour growth are marked by the stage-specific embryonic antigen SSEA-1. PMID: 21857669
    45. NEU4 plays an important role in control of sialyl Lewis antigen expression and its impairment in colon cancer PMID: 21521691
    46. CD15-expressing nodular lymphocyte-predominant Hodgkin lymphoma PMID: 21457163
    47. FUT4 inhibited cell apoptosis through decreasing the expression of apoptotic proteins and increasing the expression of anti-apoptotic protein Bcl-2 PMID: 21337384
    48. The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach. PMID: 20965272
    49. In endometrial tissues, knockdown of FUT4 expression reduces expression of Lewis Y antigen but not of integrin alphavbeta3. PMID: 20605574
    50. Findings suggest the important role of the CD11b+/CD14/CD15+/CD33+ MDSCs in mediating immunosuppression in NSCLC. PMID: 19572148

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
  • 蛋白家族：
    Glycosyltransferase 10 family
  • 数据库链接：

    HGNC: 4015

    OMIM: 104230

    KEGG: hsa:2526

    STRING: 9606.ENSP00000351602

    UniGene: Hs.390420