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  4. Recombinant Human ATPase WRNIP1 (WRNIP1)

Recombinant Human ATPase WRNIP1 (WRNIP1)

  • 中文名称：
    人WRNIP1重组蛋白
  • 货号：
    CSB-YP836298HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WRNIP1重组蛋白
  • 货号：
    CSB-EP836298HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WRNIP1重组蛋白
  • 货号：
    CSB-EP836298HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WRNIP1重组蛋白
  • 货号：
    CSB-BP836298HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WRNIP1重组蛋白
  • 货号：
    CSB-MP836298HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WRNIP1
  • Uniprot No.：
  • 别名：
    ATPase WRNIP 1; ATPase WRNIP1; bA420G6.2; FLJ22526; Putative helicase RUVBL; RP11 420G6.2; Werner helicasae interacting protein 1; Werner helicasae interacting protein; Werner helicase interacting protein isoform 2; Werner helicase-interacting protein 1; WHIP; WRIP1_HUMAN; WRNIP 1; WRNIP; Wrnip1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-665
  • 氨基酸序列
    MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGSHRAGER AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA RLIPDFPVAR SSSPGRKGSG KRPAAAAAAG SASPRSWDEA EAQEEEEAVG DGDGDGDADA DGEDDPGHWD ADAAEAATAF GASGGGRPHP RALAAEEIRQ MLQGKPLADT MRPDTLQDYF GQSKAVGQDT LLRSLLETNE IPSLILWGPP GCGKTTLAHI IASNSKKHSI RFVTLSATNA KTNDVRDVIK QAQNEKSFFK RKTILFIDEI HRFNKSQQDT FLPHVECGTI TLIGATTENP SFQVNAALLS RCRVIVLEKL PVEAMVTILM RAINSLGIHV LDSSRPTDPL SHSSNSSSEP AMFIEDKAVD TLAYLSDGDA RAGLNGLQLA VLARLSSRKM FCKKSGQSYS PSRVLITEND VKEGLQRSHI LYDRAGEEHY NCISALHKSM RGSDQNASLY WLARMLEGGE DPLYVARRLV RFASEDIGLA DPSALTQAVA AYQGCHFIGM PECEVLLAQC VVYFARAPKS IEVYSAYNNV KACLRNHQGP LPPVPLHLRN APTRLMKDLG YGKGYKYNPM YSEPVDQEYL PEELRGVDFF KQRRC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
  • 基因功能参考文献：
    1. findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. PMID: 29053956
    2. The s show that WRNIP1 is directly involved in preventing uncontrolled MRE11-mediated degradation of stalled replication forks by promoting RAD51 stabilization on ssDNA. PMID: 27242363
    3. We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type PMID: 27062441
    4. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation PMID: 25139235
    5. Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation. PMID: 22209848
    6. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC) and set forth to investigate a role for the protein positioned at the NPC. PMID: 20676042
    7. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta-mediated DNA synthesis and that its ATPase activity is utilized to sense DNA ends and to regulate the extent of stimulation. PMID: 15670210
    8. Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain PMID: 17550899
    9. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions PMID: 18842586

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    AAA ATPase family, RarA/MGS1/WRNIP1 subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 20876

    OMIM: 608196

    KEGG: hsa:56897

    STRING: 9606.ENSP00000370150

    UniGene: Hs.236828