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  4. Recombinant Human AN1-type zinc finger protein 2B (ZFAND2B)

Recombinant Human AN1-type zinc finger protein 2B (ZFAND2B)

  • 中文名称：
    人ZFAND2B重组蛋白
  • 货号：
    CSB-YP823888HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZFAND2B重组蛋白
  • 货号：
    CSB-EP823888HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZFAND2B重组蛋白
  • 货号：
    CSB-EP823888HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZFAND2B重组蛋白
  • 货号：
    CSB-BP823888HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZFAND2B重组蛋白
  • 货号：
    CSB-MP823888HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZFAND2B
  • Uniprot No.：
  • 别名：
    ZFAND2B; AIRAPL; AN1-type zinc finger protein 2B; Arsenite-inducible RNA-associated protein-like protein; AIRAP-like protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-257
  • 氨基酸序列
    MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA QHHCGSAYQK DIQVPVCPLC NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC ERAGCRQREM MKLTCERCSR NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS RAQAVASTST VPSPSQTMPS CTSPSRATTR SPSWTAPPVI ALQNGLSEDE ALQRALEMSL AETKPQVPSC QEEEDLALAQ ALSASEAEYQ RQQAQSRSSK PSNCSLC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
  • 基因功能参考文献：
    1. Results demonstrate that on specific translocation inhibition, a p97-AIRAPL complex directly binds and regulates the efficient processing of polyubiquitinated pQC substrates by the UPS. Results also demonstrate p97's role in pQC processing of preproinsulin in cases of naturally occurring mutations within the signal sequence of insulin. PMID: 26337389
    2. Consistent with its proposed role as a tumor suppressor of myeloid transformation, AIRAPL expression is widely abrogated in human myeloproliferative disorders. PMID: 26692333
    3. Zinc finger proteins may be associated with pathophysiology of severe dry eye syndrome. PMID: 24215362
    4. AIRAPL binds to p97 and forms a complex in the endoplasmic reticulum membrane. PMID: 24160817
    5. An AIP-1 human homologue, ZFAND2B, has a similar protective effect against Abeta toxicity. PMID: 19414486

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Lipid-anchor.
  • 数据库链接：

    HGNC: 25206

    OMIM: 613474

    KEGG: hsa:130617

    STRING: 9606.ENSP00000289528

    UniGene: Hs.534540