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  4. Recombinant Human 60S ribosomal protein L26 (RPL26)

Recombinant Human 60S ribosomal protein L26 (RPL26)

  • 中文名称：
    人RPL26重组蛋白
  • 货号：
    CSB-YP020207HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RPL26重组蛋白
  • 货号：
    CSB-EP020207HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RPL26重组蛋白
  • 货号：
    CSB-EP020207HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RPL26重组蛋白
  • 货号：
    CSB-BP020207HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RPL26重组蛋白
  • 货号：
    CSB-MP020207HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RPL26
  • Uniprot No.：
  • 别名：
    PL26L1; 60S ribosomal protein L26; 60S ribosomal protein L26 like 1; DBA11; FLJ46904; L26; OTTHUMP00000135333; PTB associated splicing factor; Ribosomal protein L26 ; Ribosomal protein L26 homolog; Ribosomal protein L26 like 1; Ribosomal protein L26 pseudogene 1; RL26_HUMAN; rpl26; RPL26P1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-145
  • 氨基酸序列
    MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the large ribosomal subunit.
  • 基因功能参考文献：
    1. ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA PMID: 28288992
    2. In colorectal tumor cells RPL26 regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation. PMID: 27825141
    3. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
    4. The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis PMID: 22868929
    5. Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia. PMID: 22431104
    6. suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26 PMID: 22433872
    7. Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation. PMID: 18951086

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  • 相关疾病：
    Diamond-Blackfan anemia 11 (DBA11)
  • 蛋白家族：
    Universal ribosomal protein uL24 family
  • 数据库链接：

    HGNC: 10327

    OMIM: 603704

    KEGG: hsa:6154

    STRING: 9606.ENSP00000293842

    UniGene: Hs.482144