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  4. Recombinant Human 3-keto-steroid reductase (HSD17B7), partial

Recombinant Human 3-keto-steroid reductase (HSD17B7), partial

  • 中文名称：
    人HSD17B7重组蛋白
  • 货号：
    CSB-YP010776HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HSD17B7重组蛋白
  • 货号：
    CSB-EP010776HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HSD17B7重组蛋白
  • 货号：
    CSB-EP010776HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HSD17B7重组蛋白
  • 货号：
    CSB-BP010776HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HSD17B7重组蛋白
  • 货号：
    CSB-MP010776HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HSD17B7
  • Uniprot No.：
  • 别名：
    HSD17B7; 17HSD7; SDR37C1; UNQ2563/PRO6243; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase; Estradiol 17-beta-dehydrogenase 7; Short chain dehydrogenase/reductase family 37C member 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.; Does not have enzymatic activities toward E1 and DHT.
  • 基因功能参考文献：
    1. Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. PMID: 28645527
    2. Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated. PMID: 28554725
    3. the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone. PMID: 25966904
    4. 17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells. PMID: 25257817
    5. The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium PMID: 19735314
    6. 17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells PMID: 23300627
    7. Data show that apicidin significantly lowers HSD17B1 transcript and protein levels in endometrial adenocarcinoma cells, with no significant effect on HSD17B1 transcript stability. PMID: 21086175
    8. estradiol stimulates HSD17B7 transcriptional activity in breast cancer cells through a novel mechanism requiring NF1 and strongly suggest a positive feedback mechanism, increasing estradiol synthesis causing growth of estrogen-dependent breast cancers PMID: 21372145
    9. increased expression of HSD17B7 is associated with breast cancer. PMID: 20215536
    10. HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism PMID: 12829805
    11. Comparison of the promoter region of the human and murine gene. PMID: 15862973
    12. The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes. PMID: 16356630
    13. Results provide unequivocal evidence for a role of 17beta-hydroxysteroid dehydrogenase type-7 in cholesterol biosynthesis. PMID: 16901934
    14. 17beta-hydroxysteroid dehydrogenase type 7(17beta-HSD type 7)was significantly upregulated in ovarian tissue of patients with ovarian endometriosis. PMID: 17454161
    15. 17-beta hydroxysteroid dehydrogenase type 7 (HSD17B7) -shRNA sequences were designed and tested for their effectiveness. PMID: 17498944

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, ERG27 subfamily
  • 组织特异性：
    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested.; [Isoform 3]:
  • 数据库链接：

    HGNC: 5215

    OMIM: 606756

    KEGG: hsa:51478

    STRING: 9606.ENSP00000254521

    UniGene: Hs.492925