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  4. Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)

Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)

  • 中文名称：
    人HAAO重组蛋白
  • 货号：
    CSB-YP010112HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HAAO重组蛋白
  • 货号：
    CSB-EP010112HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HAAO重组蛋白
  • 货号：
    CSB-EP010112HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HAAO重组蛋白
  • 货号：
    CSB-BP010112HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HAAO重组蛋白
  • 货号：
    CSB-MP010112HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HAAO
  • Uniprot No.：
  • 别名：
    3 HAO; 3 hydroxyanthranilate 3 4 dioxygenase; 3 hydroxyanthranilate dioxygenase; 3 hydroxyanthranilate oxygenase; 3 hydroxyanthranilic acid dioxygenase; 3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; 3HAO_HUMAN; haao; HAD; HAO
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-286
  • 氨基酸序列
    MERRLGVRAW VKENRGSFQP PVCNKLMHQE QLKVMFIGGP NTRKDYHIEE GEEVFYQLEG DMVLRVLEQG KHRDVVIRQG EIFLLPARVP HSPQRFANTV GLVVERRRLE TELDGLRYYV GDTMDVLFEK WFYCKDLGTQ LAPIIQEFFS SEQYRTGKPI PDQLLKEPPF PLSTRSIMEP MSLDAWLDSH HRELQAGTPL SLFGDTYETQ VIAYGQGSSE GLRQNVDVWL WQLEGSSVVT MGGRRLSLAP DDSLLVLAGT SYAWERTQGS VALSVTQDPA CKKPLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
  • 基因功能参考文献：
    1. Here, the first crystal structure of human 3-HAO with the native iron bound in its active site is presented, together with an additional structure with zinc (a known inhibitor of human 3-HAO) bound in the active site. PMID: 28375145
    2. Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors. PMID: 20211485
    3. GTF2A1 alone, or GTF2A1 plus HAAO are excellent candidate biomarkers for detecting Ovarian cancer PMID: 19724865
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    3-HAO family
  • 数据库链接：

    HGNC: 4796

    OMIM: 604521

    KEGG: hsa:23498

    STRING: 9606.ENSP00000294973

    UniGene: Hs.368805