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  4. Recombinant Human 3-hydroxyacyl-CoA dehydratase 4 (PTPLAD2), partial

Recombinant Human 3-hydroxyacyl-CoA dehydratase 4 (PTPLAD2), partial

  • 中文名称：
    人HACD4重组蛋白
  • 货号：
    CSB-YP716579HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HACD4重组蛋白
  • 货号：
    CSB-EP716579HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HACD4重组蛋白
  • 货号：
    CSB-EP716579HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HACD4重组蛋白
  • 货号：
    CSB-BP716579HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HACD4重组蛋白
  • 货号：
    CSB-MP716579HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HACD4
  • Uniprot No.：
  • 别名：
    HACD4; PTPLAD2; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
  • 基因功能参考文献：
    1. association of HACD4 haplotypes with atherosclerotic phenotypes connotes a further validation and replication in larger cohorts as well as functional studies to enlighten the potential mechanism of its action in pathophysiology of atherosclerosis. PMID: 29031776
    2. PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces STAT3 phosphorylation. PMID: 24530685
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Very long-chain fatty acids dehydratase HACD family
  • 组织特异性：
    Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta.
  • 数据库链接：

    HGNC: 20920

    OMIM: 615941

    KEGG: hsa:401494

    STRING: 9606.ENSP00000419503

    UniGene: Hs.716678