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  4. Recombinant Helicobacter pylori Urease subunit beta (ureB)

Recombinant Helicobacter pylori Urease subunit beta (ureB)

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  • 中文名称：
    幽门螺旋杆菌ureB重组蛋白
  • 货号：
    CSB-YP300910HUV
  • 规格：
    ￥528
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP300910HUV could indicate that this peptide derived from Yeast-expressed Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureB.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP300910HUV could indicate that this peptide derived from Yeast-expressed Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureB.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ureB
  • Uniprot No.：
  • 别名：
    HP_0072; hpuB; URE1_HELPY; Urea amidohydrolase subunit beta; Urease subunit beta; ureB
  • 种属：
    Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    63.7kDa
  • 表达区域：
    1-569aa
  • 氨基酸序列
    MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    A full-length Helicobacter pylori Urease subunit beta (ureB) ORF (1-569aa) with an N-terminal 6xHis-tag was expressed in the yeast. The forming protein is the Recombinant Helicobacter pylori ureB protein. This ureB protein was verified by SDS-PAGE and LC-MS/MS Analyses. Its purity is greater than 90%. It has a calculated molecular mass of 63.7 kDa. This recombinant ureB protein may be used as an immunogen for specific antibody production or in the studies of gastritis and gastric cancer.

    UreB is a structural subunit of urease that is critical to the metabolism and virulence of Helicobacter pylori. Urease is also necessary for Helicobacter pylori's colonization of the gastric mucosa and is a potent immunogen that triggers a vigorous immune response. Chronic Helicobacter pylori (H. pylori) infection to gastric mucosa is a common cause for gastritis and increases the risk of gastric cancer.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
  • 基因功能参考文献：
    1. Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. PMID: 26214524
  • 亚细胞定位：
    Cytoplasm. Note=Also associates with the outer membrane upon autolysis of neighboring bacteria.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Urease alpha subunit family
  • 数据库链接：

    KEGG: heo:C694_00350

    STRING: 85962.HP0072