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  4. Recombinant Drosophila melanogaster WW domain-containing oxidoreductase (Wwox)

Recombinant Drosophila melanogaster WW domain-containing oxidoreductase (Wwox)

  • 中文名称：
    黑腹果蝇Wwox重组蛋白
  • 货号：
    CSB-YP893301DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Wwox重组蛋白
  • 货号：
    CSB-EP893301DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Wwox重组蛋白
  • 货号：
    CSB-EP893301DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Wwox重组蛋白
  • 货号：
    CSB-BP893301DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Wwox重组蛋白
  • 货号：
    CSB-MP893301DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Wwox
  • Uniprot No.：
  • 别名：
    Wwox; CG7221; WW domain-containing oxidoreductase; EC 1.1.1.-
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-409
  • 氨基酸序列
    MIALPDTDSE DELPPGWEER ATDDGTVCYV NQQGKTSQWT HPRTGRSKRI TGELPLGWEK YYDEQGKRFM FLNKETQQRT NVDPRLAFAV EEPTQNVAQV RQRFDSCSTA LQVLHGKDLH GRTALITGAN CGIGYETARS LAHHGCEIIF ACRNRSSAEA AIERIAQERP AARSRCRFAA LDLSSLRSVQ RFVEEIKQSV SHIDYLILNA GVFALPYTRT VDGLETTFQV SHLSHFYLTL QLETLFDYKT RIIVLSSESH RFANLPVENL AVHHLSPPPE KYWSMMAYNN AKLCNVLFAQ ELAQRWKQRG ISVFSLHPGN MVSSDLSRNY WFYRLLFAIV RPFTKSLQQA AATSIYCATA NELTGLSGLY FNNCFFCEPS KLSKSAALQQ QLWKLSENLI AELVEQEQH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling.
  • 基因功能参考文献：
    1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. PMID: 26390919
    2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity. PMID: 26302329
    3. Aberrant WWOX expression contributes to the altered metabolism in cancer. PMID: 25595186
    4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX PMID: 21075834
    5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX PMID: 16007179

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 数据库链接：

    KEGG: dme:Dmel_CG7221

    STRING: 7227.FBpp0079172

    UniGene: Dm.19795