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  4. Recombinant Drosophila melanogaster Tyrosine-protein kinase receptor torso (tor), partial

Recombinant Drosophila melanogaster Tyrosine-protein kinase receptor torso (tor), partial

  • 货号：
    CSB-YP323590DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP323590DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP323590DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP323590DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP323590DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    tor
  • Uniprot No.：
  • 别名：
    tor; CG1389; Tyrosine-protein kinase receptor torso; EC 2.7.10.1
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation.
  • 基因功能参考文献：
    1. Cic functions are independent of RTK regulation and may depend on cofactor-assisted DNA binding. PMID: 29432195
    2. Mechanistically, the s identify foxo and mTOR homologue, Tor as important regulators of germline stem cells quiescence following exposure to ionizing radiation. foxo is required for entry in quiescence, while Tor is essential for cell cycle reentry. PMID: 28925355
    3. Our study revealed a novel role for Torso in the fat body with respect to regulation of insulin/TOR signaling and body size. PMID: 27126913
    4. Data suggest that Tor signaling governs Yki (Yorkie protein) action after reaching nucleus by allowing access to target genes via Hpo (Hippo protein) pathway; Tor also promotes wing growth by liberating Yki from nuclear seclusion. PMID: 26474042
    5. The conserved Tor metabolic sensing pathway regulates yolk catabolism. PMID: 26395483
    6. down-regulates Capicua at the embryonic termini PMID: 20404518
    7. Data indicate that Torso-like (Tsl) and receptor tyrosine kinase Torso (Tor) have opposing effects on body size. PMID: 23959885
    8. repeated Torso activation is linked to a duplication and differential expression of a ligand-encoding gene, the acquisition of distinct enhancers in the torso-like promoter and the recruitment of proteins independently required for embryogenesis PMID: 23094137
    9. Torso reduces the stability of Capicua by controlling the rates of its nucleocytoplasmic transport PMID: 23048183
    10. The Torso RTK is required for proper migration of primordial germ cells in Drosophila. PMID: 21618099
    11. characterized a new psq loss-of-function allele, psq(rum), which specifically affects signaling by the Torso (Tor) receptor tyrosine kinase (RTK) PMID: 21098720
    12. closca is a gene encoding a new member of a group of proteins that act non-redundantly in vitelline membrane biogenesis and in Torso signalling; Nasrat protein is another member of this group incorporated into the vitelline membrane PMID: 20457146
    13. During embryogenesis, the activated Torso receptor tyrosine kinase (TOR RTK) pathway activates tailless (tll) expression by a relief-of-repression mechanism. PMID: 12128207
    14. STAT, encoded by marelle (mrl; DStat92E), is essential for the gain-of-function mutant Tor (Tor(GOF)) to activate ectopic gene expression PMID: 12183376
    15. Data show that in Drosophila, the receptor tyrosine kinase Torso activates both STAT92E and Ras1 during the early phase of primordial germ cell development. PMID: 14602078
    16. the Torso RTK pathway has a role in downregulation of Capicua repression and tailless activation in the Drosophila embryo PMID: 16753285
    17. A specific feature of Torso pathway signaling is the fact that the cell-cell contact at the origin of the triggering mechanism is established much earlier than the signaling mechanism itself. PMID: 17595301
    18. lack of pgc partly ameliorates the cellularization defect of tor mutants, thus revealing a functional antagonism between pgc and tor in the specification of germline and somatic properties. PMID: 19644502

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 数据库链接：

    KEGG: dme:Dmel_CG1389

    STRING: 7227.FBpp0111751

    UniGene: Dm.512