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  4. Recombinant Drosophila melanogaster Protein extra-macrochaetae (emc)

Recombinant Drosophila melanogaster Protein extra-macrochaetae (emc)

  • 货号：
    CSB-YP322441DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP322441DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP322441DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP322441DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP322441DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    emc
  • Uniprot No.：
  • 别名：
    emc; CG1007Protein extra-macrochaetae
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-199
  • 氨基酸序列
    MKSLTAVCQT GASGMPALNA SGRIQRHPTH RGDGENAEMK MYLSKLKDLV PFMPKNRKLT KLEIIQHVID YICDLQTELE THPEMGNFDA AAALTAVNGL HEDEDSDMED ADAEAEAEVD PDILAQRLNA EQPAKVSSPA ARLPLTDRQT PNTLVAPAHP QQHQQQQQLQ LQQQQLQSQQ QLSNSLATPQ NAEKDSRQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer.
  • 基因功能参考文献：
    1. Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs. PMID: 25715400
    2. Hh drives and Emc impedes the progression of the furrow across the developing retina. PMID: 24406336
    3. argue that the role emc, h and sr in development of the flight apparatus preceded their activities for macrochaete patterning PMID: 24384389
    4. The role of Emc in eye development is to impose order on the retina by regulating the activity of the Hedgehog and Wingless signaling pathways. PMID: 23536565
    5. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. PMID: 23118874
    6. emc lies downstream of fs(1)K10, gurken and EGFR in the Grk/EGFR signalling pathway and it participates in controlling Broad-Complex expression at late stages of oogenesis. PMID: 16026970
    7. Results show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters. PMID: 19118542

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG1007

    STRING: 7227.FBpp0072477

    UniGene: Dm.2147