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  4. Recombinant Drosophila melanogaster Probable lysine-specific demethylase 4A (Kdm4A)

Recombinant Drosophila melanogaster Probable lysine-specific demethylase 4A (Kdm4A)

  • 中文名称：
    黑腹果蝇Kdm4A重组蛋白
  • 货号：
    CSB-YP894170DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Kdm4A重组蛋白
  • 货号：
    CSB-EP894170DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Kdm4A重组蛋白
  • 货号：
    CSB-EP894170DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Kdm4A重组蛋白
  • 货号：
    CSB-BP894170DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Kdm4A重组蛋白
  • 货号：
    CSB-MP894170DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm4A
  • Uniprot No.：
  • 别名：
    Kdm4A; CG15835; Probable lysine-specific demethylase 4A; EC 1.14.11.-; Probable JmjC domain-containing histone demethylation protein 3A
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-495
  • 氨基酸序列
    MSTRSSFADE EQNKVPRIMT FRPSYEEFQN FSAYIEYIES RGAHLAGLAK IQPPAEWVPR KSGYDIDNIN MTIPAPICQV VTGAHGVYQQ INIQQRRQMT LRQFMEKANS ELHQTPRHFD YDDLERKYWK NITYISPLYA ADVKGSLSDE DLDVWNIGRL DTILNLVNTD YNIIIDGVNT AYLYFGMWKS SFAWHTEDMD LYSINYLHFG APKTWYAIPP AYGRRLEKLA NETFSENYQE CNAYLRHKMT MISPKVLRQH NIPYNKITQE AGEIMITFPF GYHAGFNHGF NGAESTNFAS KRWIEYGKRA SICRCRSDMV KISMETFVRR FQPERYDNWL KGQDMGCHPE EPGKICAAAP PTLNEYEKQE NLRAAKSEEE SPQKRGCSLA GNGCERNAES AEDVDDKASV SSYSSCRQLQ PVVKLRKLPT IASVPEPSSA PKRYDFNTEA VVRVKRLWNE LPCPDRGANL LTNGVVKNTK RMRFQTKVLT LDDED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能参考文献：
    1. dKDM4A, in addition to its previously characterized role in euchromatin, utilizes both enzymatic and structural mechanisms to regulate heterochromatin organization and functions. PMID: 28743002
    2. Jra recruits the HP1a/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation PMID: 25945750
    3. Appropriate expression levels for some dKDM4A-regulated genes rely on the demethylase activity of dKDM4A, whereas others do not. PMID: 23195220
    4. These results suggest a function of HP1a in transcription facilitating H3K36 demethylation at transcribed and/or heterochromatin regions by dKDM4A (CG15835). PMID: 19061644
    5. these results have implications for the role of the epigenetic regulator Dmel\Kdm4A in the control of genes involved in life span and male-specific sex determination in the fly. PMID: 19786080

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 数据库链接：

    KEGG: dme:Dmel_CG15835

    STRING: 7227.FBpp0087961

    UniGene: Dm.4139