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  4. Recombinant Drosophila melanogaster Probable N-acetyltransferase san (san)

Recombinant Drosophila melanogaster Probable N-acetyltransferase san (san)

  • 中文名称：
    黑腹果蝇san重组蛋白
  • 货号：
    CSB-YP882048DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇san重组蛋白
  • 货号：
    CSB-EP882048DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇san重组蛋白
  • 货号：
    CSB-EP882048DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇san重组蛋白
  • 货号：
    CSB-BP882048DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇san重组蛋白
  • 货号：
    CSB-MP882048DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    san
  • Uniprot No.：
  • 别名：
    san; span; CG12352; Probable N-acetyltransferase san; EC 2.3.1.258; N-epsilon-acetyltransferase san; EC 2.3.1.-; Protein atado; Protein separation anxiety
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-184
  • 氨基酸序列
    MTRSSIELGD VTPHNIKQLK KLNTVVFPVS YNDKFYVDVL EAGELAKLAY YNDIVVGAVC CRIDNTENQR RLYIMTLGCL SPYRRLGIGT VMFEHIMNFA EKDGNFDSIF LHVQINNNGA IEFYKKFGFE IVDTKEQYYK RIEPADAHVL QKTLRRTAPN SNSTATSTTA NSNSRSKARQ FTFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates. Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. Required for the interaction between Scc1/vtd and SMC3, possibly by mediating N-terminal acetylation of Scc1/vtd.; (Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body.
  • 基因功能参考文献：
    1. Results suggest that during tissue proliferation San behaves as general regulator of sister chromatid cohesion, as it facilitates the correct interaction between cohesin subunits Scc1/Rad21/Vtd and Smc3. Also, the results suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, which is subsequently required for the correct establishment and maintenance of sister chromatid cohesion. PMID: 27996020
    2. plays vital roles in regulating sister chromatid cohesion during Drosophila mitosis PMID: 14653991
    3. san is required in vivo for normal mitosis of different types of somatic cells. PMID: 18801358
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Acetyltransferase family
  • 数据库链接：

    KEGG: dme:Dmel_CG12352

    STRING: 7227.FBpp0087227

    UniGene: Dm.1821