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  4. Recombinant Drosophila melanogaster Phosrestin-1 (Arr2)

Recombinant Drosophila melanogaster Phosrestin-1 (Arr2)

  • 货号：
    CSB-YP325636DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP325636DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP325636DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP325636DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP325636DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arr2
  • Uniprot No.：
  • 别名：
    Arr2; ArrB; CG5962Phosrestin-1; 49 kDa arrestin-like protein; Arrestin-2; Arrestin-B; Phosrestin I
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-401
  • 氨基酸序列
    MVVSVKVFKK ATPNGKVTFY LGRRDFIDHI DYCDPVDGVI VVEPDYLKNR KVFGQLATTY RYGREEDEVM GVKFSKELIL CREQIVPMTN PNMEMTPMQE KLVRKLGSNA YPFTFHFPPN SPSSVTLQQE GDDNGKPLGV EYTIRAFVGD SEDDRQHKRS MVSLVIKKLQ YAPLNRGQRL PSSLVSKGFT FSNGKISLEV TLDREIYYHG EKTAATVQVS NNSKKSVKSI KCFIVQHTEI TMVNAQFSKH VAQLETKEGC PITPGANLTK TFYLIPLAAN NKDRHGIALD GHLKDEDVNL ASSTMVQEGK STGDACGIVI SYSVRIKLNC GTLGGEMQTD VPFKLLQPAP GTIEKKRSNA MKKMKSIEQH RNVKGYYQDD DDNIVFEDFA KMRMNNVNMA D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probably plays an important role in the photoreceptor transduction.
  • 基因功能参考文献：
    1. Rapid calcium/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction. PMID: 22764229
    2. This study indicated that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx. PMID: 20869596
    3. We developed a steady-state stochastic model to interpret the dependence of the PDA on effective light intensity and arrestin content and to help deduce the arrestin to rhodopsin ratio from the sensitivity and PDA data. PMID: 19924417
    4. a constitutively active arrestin mutant can both induce agonist-independent internalization and stabilize the agonist-high affinity state of an arrestin-insensitive G protein coupled receptor. PMID: 12695524
    5. news: beta-arrestin is now identified as a regulator of ubiquination and degradation of the Notch receptor PMID: 16319967
    6. data suggest a novel model of arrestin-2 regulation mediated by inositol hexakisphosphate PMID: 16439357
    7. Data show that the endocytic adapter protein AP-2 is essential for rhodopsin endocytosis through an arrestin2-AP-2beta interaction. PMID: 16835270
    8. CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2 PMID: 19254957

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  • 蛋白家族：
    Arrestin family
  • 组织特异性：
    Inner and outer segments, and the inner plexiform regions of the retina.
  • 数据库链接：

    KEGG: dme:Dmel_CG5962

    STRING: 7227.FBpp0076326

    UniGene: Dm.7211