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  4. Recombinant Drosophila melanogaster MOB kinase activator-like 1 (mats)

Recombinant Drosophila melanogaster MOB kinase activator-like 1 (mats)

  • 中文名称：
    黑腹果蝇mats重组蛋白
  • 货号：
    CSB-YP842576DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇mats重组蛋白
  • 货号：
    CSB-EP842576DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇mats重组蛋白
  • 货号：
    CSB-EP842576DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇mats重组蛋白
  • 货号：
    CSB-BP842576DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇mats重组蛋白
  • 货号：
    CSB-MP842576DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    mats
  • Uniprot No.：
  • 别名：
    mats; CG13852; MOB kinase activator-like 1; Mob as tumor suppressor protein 1; Dmob1; Mps one binder kinase activator-like 1
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-219
  • 氨基酸序列
    MDFLFGSRSS KTFKPKKNIP EGTHQYDLMK HAAATLGSGN LRNAVALPDG EDLNEWVAVN TVDFFNQINM LYGTITEFCT EETCGIMSAG PKYEYHWADG LTVKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFHSSAKT ILKRLFRVYA HIYHQHFTEV VTLGEEAHLN TSFKHFIFFV QEFNLIERRE LAPLQELIDK LTAKDERQI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.
  • 基因功能参考文献：
    1. Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control PMID: 24016667
    2. These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size. PMID: 19913529
    3. described growth inhibitory functions for a Mob superfamily protein, termed Mats; loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth [Mats] PMID: 15766530
    4. mats regulation in development was studied. PMID: 18472003
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with wts and cyclin E at the centrosome.
  • 蛋白家族：
    MOB1/phocein family
  • 组织特异性：
    Ubiquitously expressed at low levels in developing tissues (at protein level).
  • 数据库链接：

    KEGG: dme:Dmel_CG13852

    STRING: 7227.FBpp0083624

    UniGene: Dm.3572