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  4. Recombinant Drosophila melanogaster Insulin-like receptor (InR), partial

Recombinant Drosophila melanogaster Insulin-like receptor (InR), partial

  • 货号：
    CSB-YP357600DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP357600DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP357600DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP357600DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP357600DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    InR
  • Uniprot No.：
  • 别名：
    InR; dinr; Dir-a; Inr-a; CG18402Insulin-like receptor; dIR; dInr; EC 2.7.10.1; dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2]
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination.
  • 基因功能参考文献：
    1. a sensory neuron-specific function of InR regulates the persistence of injury-associated hypersensitivity. PMID: 29752280
    2. Impairment of insulin signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin] PMID: 22786647
    3. it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals. PMID: 29372799
    4. Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor. PMID: 26020640
    5. Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress PMID: 25937233
    6. results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep PMID: 25581915
    7. This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress. PMID: 25966593
    8. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling. PMID: 23935447
    9. InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation. PMID: 24026119
    10. Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis PMID: 23022298
    11. controls growth and size by modulating PtdInsP(3) levels. PMID: 12163412
    12. required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system; functions as a guidance receptor for the adapter protein Dock/Nck PMID: 12702880
    13. InR regulates cell growth and proliferation through the dP13K/dAkt pathway. PMID: 12893776
    14. Genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. PMID: 15592467
    15. insulin-like receptor pathway incorporates 4E-BP resistant cellular IRES containing mRNAs to functionally couple transcriptional activation with differential translational control in a cell that is otherwise translationally repressed by 4E-BP PMID: 17234883
    16. InR/Foxo signaling controls cell cycle progression by modulating dmyc expression and dMyc transcriptional activity PMID: 19211682
    17. In Drosophila melanogaster the level and pattern of variation at the 8-kb region of InR surveyed did not provide any indication of a recent selective event in this region. PMID: 19398492

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Widely distributed throughout the embryo. Expressed at high levels in the embryonic nervous system. Larval expression is limited to the nervous system and all imaginal disks. Expressed at high levels in the adult nervous system and ovaries.
  • 数据库链接：

    KEGG: dme:Dmel_CG18402

    STRING: 7227.FBpp0288669

    UniGene: Dm.1271