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  4. Recombinant Drosophila melanogaster Bursicon (burs)

Recombinant Drosophila melanogaster Bursicon (burs)

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  • 中文名称：
    Recombinant Drosophila melanogaster Bursicon(burs)
  • 货号：
    CSB-EP894207DLU
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Burs
  • Uniprot No.：
  • 别名：
    Burs; burs-alpha; CG13419Bursicon; Bursicon subunit alpha; Cuticle-tanning hormone
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    42.5kDa
  • 表达区域：
    33-173aa
  • 氨基酸序列
    QPDSSVAATDNDITHLGDDCQVTPVIHVLQYPGCVPKPIPSFACVGRCASYIQVSGSKIWQMERSCMCCQESGEREAAVSLFCPKVKPGERKFKKVLTKAPLECMCRPCTSIEESGIIPQEIAGYSDEGPLNNHFRRIALQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.
  • 基因功能参考文献：
    1. Bursicon-alpha subunit modulates LGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-beta. PMID: 27191973
    2. acts in cuticle synthesis and degradation by regulating the expression of cuticular protein and chitin metabolizing related genes PMID: 25821138
    3. results show that the functions thought to be subserved by CCAP are partially effected by bursicon, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself. PMID: 22593051
    4. Study provides evidence that bursicon release can precede the initiation of larval ecdysis, and that bursicon tans the puparium; results establish bursicon signaling as essential to insect growth and development. PMID: 20807433
    5. identify here Drosophila bioactive bursicon as a heterodimer made of two cystine knot polypeptides PMID: 15811337
    6. the Bursicon/Rickets signaling pathway is necessary for both wing expansion and initiation of the EMT that leads to removal of the epithelial cells from the wing. PMID: 18780731
    7. the results of this study reveal novel neuromodulatory functions for bursicon and support the hypothesis that the BSEG are essential for orchestrating both the behavioral and somatic processes underlying wing expansion. PMID: 19118171

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in one to two pairs of neurons in each of the thoracic and abdominal neuromeres of the larval CNS. Coexpressed with CCAP in most CCAP-specific neurons. Coexpressed with Pburs in four bilateral neurons in thoracic and abdominal neuromeres of the
  • 数据库链接：

    KEGG: dme:Dmel_CG13419

    STRING: 7227.FBpp0083529

    UniGene: Dm.25481