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  4. Recombinant Drosophila melanogaster Apoptosis 2 inhibitor (Iap2)

Recombinant Drosophila melanogaster Apoptosis 2 inhibitor (Iap2)

  • 中文名称：
    黑腹果蝇Diap2重组蛋白
  • 货号：
    CSB-YP635521DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Diap2重组蛋白
  • 货号：
    CSB-EP635521DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Diap2重组蛋白
  • 货号：
    CSB-EP635521DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Diap2重组蛋白
  • 货号：
    CSB-BP635521DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Diap2重组蛋白
  • 货号：
    CSB-MP635521DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Diap2
  • Uniprot No.：
  • 别名：
    Diap2; DIHA; Iap2; Ilp; CG8293Death-associated inhibitor of apoptosis 2; Apoptosis 2 inhibitor; IAP homolog A; IAP-like protein; ILP; dILP; Inhibitor of apoptosis 2
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-498
  • 氨基酸序列
    MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH VRIDRWEYGD QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDNEGNSVVD SPESCSCPDL LLEANRLVTF KDWPNPNITP QALAKAGFYY LNRLDHVKCV WCNGVIAKWE KNDNAFEEHK RFFPQCPRVQ MGPLIEFATG KNLDELGIQP TTLPLRPKYA CVDARLRTFT DWPISNIQPA SALAQAGLYY QKIGDQVRCF HCNIGLRSWQ KEDEPWFEHA KWSPKCQFVL LAKGPAYVSE VLATTAANAS SQPATAPAPT LQADVLMDEA PAKEALALGI DGGVVRNAIQ RKLLSSGCAF STLDELLHDI FDDAGAGAAL EVREPPEPSA PFIEPCQATT SKAASVPIPV ADSIPAKPQA AEAVANISKI TDEIQKMSVA TPNGNLSLEE ENRQLKDARL CKVCLDEEVG VVFLPCGHLA TCNQCAPSVA NCPMCRADIK GFVRTFLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides. Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses rpr and hid-dependent cell death in the eye. However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway. Plays a role in regulating the expression of ion channels.
  • 基因功能参考文献：
    1. cleaved protein retains the ability to interact with immune deficiency pathway signal transduction PMID: 25968339
    2. promotes growh regulation; expression in neuroendocrine cells is nutrient-dependent PMID: 12176357
    3. DIAP1 ensures cell viability by directly inhibiting caspases. PMID: 14657035
    4. role in inhibiting DrICE PMID: 15107838
    5. precise timing of larval tissue cell death during metamorphosis is achieved through a steroid-triggered shift in the balance between the Drosophila inhibitor of apoptosis 1 and the rpr and hid death activators PMID: 15150408
    6. Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Imd pathway, which controls antimicrobial peptide expression in Drosophila. PMID: 16163390
    7. Results identify DIAP2 as an essential component of the Imd signaling cascade, protecting the organism from infiltrating microbes. PMID: 16894030
    8. diap2 may identify a point of convergence between apoptosis and immune signaling pathways PMID: 17068333
    9. Required to sustain antimicrobial peptide gene expression; inactivation results in impaired microbial resistance. PMID: 17343912
    10. Because DIAP2 efficiently interacts with drICE, our data suggest that DIAP2 controls drICE in its apoptotic and nonapoptotic roles. PMID: 18166655

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    IAP family
  • 组织特异性：
    Expressed in both principal and stellar cells of the Malphigian tubules.
  • 数据库链接：

    KEGG: dme:Dmel_CG8293

    STRING: 7227.FBpp0086432

    UniGene: Dm.7173