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  4. Recombinant Dog Platelet-activating factor acetylhydrolase (PLA2G7)

Recombinant Dog Platelet-activating factor acetylhydrolase (PLA2G7)

  • 中文名称：
    熟悉的犬PLA2G7重组蛋白
  • 货号：
    CSB-YP631704DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    熟悉的犬PLA2G7重组蛋白
  • 货号：
    CSB-EP631704DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    熟悉的犬PLA2G7重组蛋白
  • 货号：
    CSB-EP631704DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    熟悉的犬PLA2G7重组蛋白
  • 货号：
    CSB-BP631704DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    熟悉的犬PLA2G7重组蛋白
  • 货号：
    CSB-MP631704DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLA2G7
  • Uniprot No.：
  • 别名：
    PLA2G7; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; EC 3.1.1.47; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-associated phospholipase A2; LDL-PLA(2); PAF 2-acylhydrolase
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-444
  • 氨基酸序列
    IDWQDLNPV AHIRSSAWAN KIQALMAAAS IRQSRIPKGN GSYSVGCTDL MFDYTNKGTF LRLYYPSQED DHSDTLWIPN KEYFFGLSKY LGTPWLMGKI LSFFFGSVTT PANWNSPLRT GEKYPLIVFS HGLGAFRTIY SAIGIDLASH GFIVAAIEHR DGSASATYYF KDQSAAEIGN KSWSYLQELK PGDEEIHVRN EQVQKRAKEC SQALNLILDI DHGRPIKNVL DLEFDVEQLK DSIDRDKIAV IGHSFGGATV LQALSEDQRF RCGIALDAWM LPLDDAIYSR IPQPLFFINS ERFQFPENIK KMKKCYSPDK ERKMITIRGS VHQNFADFTF TTGKIVGYIF TLKGDIDSNV AIDLCNKASL AFLQKHLGLR KDFDQWDSLI EGKDENLMPG TNINITNEHD TLQNSPEAEK SNLD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.
  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 组织特异性：
    Plasma.
  • 数据库链接：

    KEGG: cfa:403848

    STRING: 9615.ENSCAFP00000030617

    UniGene: Cfa.3709