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  4. Recombinant Dog Metalloproteinase inhibitor 2 (TIMP2)

Recombinant Dog Metalloproteinase inhibitor 2 (TIMP2)

  • 中文名称：
    熟悉的犬TIMP2重组蛋白
  • 货号：
    CSB-YP879998DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    熟悉的犬TIMP2重组蛋白
  • 货号：
    CSB-EP879998DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    熟悉的犬TIMP2重组蛋白
  • 货号：
    CSB-EP879998DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    熟悉的犬TIMP2重组蛋白
  • 货号：
    CSB-BP879998DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    熟悉的犬TIMP2重组蛋白
  • 货号：
    CSB-MP879998DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TIMP2
  • Uniprot No.：
  • 别名：
    TIMP2; Metalloproteinase inhibitor 2; Tissue inhibitor of metalloproteinases 2; TIMP-2
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-220
  • 氨基酸序列
    CSCS PVHPQQAFCN ADVVIRAKAV SVKEVDSGND IYGNPIKRIQ YEIKQIKMFK GPDKDIEFIY TAPSSAVCGV SLDIGGKKEY LIAGKAEGNG KMHITLCDFI VPWDTLSSTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE KSINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
  • 基因功能参考文献：
    1. Suggest cryoplasty increases the expression of TIMP-2 and decreases the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis in the stenotic vessels. PMID: 26335992
    2. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation. PMID: 24639125
    3. This study demonstrates that MMP-9, TIMP-2 and VEGF-A expression is related to histological grade in canine mast cell tumors. PMID: 22520817
    4. The cloning of matrix metallopeptidase 2 (MMP2)and its expression with tissue inhibitor of matrix metalloproteinase 2 (TIMP2) in canine lymph nodes and lymphomas are reported. PMID: 17604063
    5. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10. PMID: 18717642

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 数据库链接：

    KEGG: cfa:403633

    STRING: 9615.ENSCAFP00000035219

    UniGene: Cfa.3497