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  4. Recombinant Dog Baculoviral IAP repeat-containing protein 5 (BIRC5)

Recombinant Dog Baculoviral IAP repeat-containing protein 5 (BIRC5)

  • 货号：
    CSB-YP814170DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP814170DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP814170DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP814170DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP814170DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    BIRC5Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-142
  • 氨基酸序列
    MGASSLPPAW QLYLKDHRVS TFKNWPFLEG CACTPDRMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLSE FLKLDKERAK NKIAKETNNK QKEFEETAKK VRCAIEQLAA AE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function.
  • 基因功能参考文献：
    1. The results indicate that survivin is commonly expressed in canine lymphomas and that survivin does not exhibit anti-apoptotic activity in canine lymphomas. PMID: 28865215
    2. These findings strongly suggest that survivin-directed therapies might be effective in treatment of canine lymphoma and osteoporosis and support evaluation of EZN-3042 in dogs with cancer. PMID: 24923332
    3. These findings suggest that survivin could play an important role in the maintenance of the hair follicle cycle as well as in tumour initiation and maintenance of cancer stem cells. PMID: 24800266
    4. The level of survivin expression increased with increasing malignancy, designating survivin as a new diagnostic marker in the assessment of malignancy of sebaceous tumours. PMID: 22681570
    5. Survivin overexpression is associated with tumor malignancy in dog. PMID: 16243724
    6. Malignant proliferation in canine hemangiosarcomas is associated with bcl-2 and survivin expression. PMID: 18479697
    7. Survivin expression is a negative prognostic factor that can predict early treatment failure of dogs that present with stage IIIa or IVa, B-cell LSA when treated with a CHOP-based protocol. PMID: 18647159
    8. Nuclear survivin was detected in transitional cell carcinoma and cystitic tissues but not in normal urinary bladder tissues. PMID: 18672973
    9. This study demonstrated survivin expression in normal canine epidermis; nuclear survivin expression in pre-neoplastic and neoplastic lesions demonstrated a possible association of survivin with development of squamous cell carcinomas in humans and dogs. PMID: 20178473

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody.
  • 蛋白家族：
    IAP family
  • 数据库链接：

    KEGG: cfa:442936

    STRING: 9615.ENSCAFP00000007914

    UniGene: Cfa.33943