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  4. Recombinant Danio rerio Protein odd-skipped-related 1 (osr1)

Recombinant Danio rerio Protein odd-skipped-related 1 (osr1)

  • 中文名称：
    斑马鱼osr1重组蛋白
  • 货号：
    CSB-YP713612DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼osr1重组蛋白
  • 货号：
    CSB-EP713612DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼osr1重组蛋白
  • 货号：
    CSB-EP713612DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼osr1重组蛋白
  • 货号：
    CSB-BP713612DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼osr1重组蛋白
  • 货号：
    CSB-MP713612DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    osr1
  • Uniprot No.：
  • 别名：
    osr1; si:dkey-199e17.1; zgc:101674; Protein odd-skipped-related 1; zOsr1
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-264
  • 氨基酸序列
    MGSKTLPAPV PLHPSLQLAN YSFLQTSNGL HLPADHMPSI YSFSALHAVH LHQWTLGYPP FTLPRCTFSK LPGLVDARFP LPSIPLFPHL VQPAKQESSG PGSGASSKSK PRFDFANLAA AATQDDALKA EDLSTNNGHV RSPSLGCLLD VAKLSSPERK PSRGRLPSKT KKEFVCKFCG RHFTKSYNLL IHERTHTDER PYTCDICHKA FRRQDHLRDH RYIHSKEKPF KCQECGKGFC QSRTLAVHKT LHMQVKELKP AKIK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification.
  • 基因功能参考文献：
    1. findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors. PMID: 25233796
    2. Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin and thereby mediate podocyte differentiation. PMID: 24722440
    3. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development. PMID: 22129829
    4. Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs PMID: 17011543
    5. osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. PMID: 18787069

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Odd C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in the germ ring mesendoderm and subsequently in the endoderm and intermediate mesoderm, prior to the expression of definitive kidney or blood markers. At 60 hpf, expressed in the glomerulus, in some patches in the eye and brain, and weakly in t
  • 数据库链接：

    KEGG: dre:450059

    STRING: 7955.ENSDARP00000023564

    UniGene: Dr.13499