Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Danio rerio Paired box protein Pax-6 (pax6a)

Recombinant Danio rerio Paired box protein Pax-6 (pax6a)

  • 货号：
    CSB-YP017492DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017492DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017492DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017492DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017492DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    pax6a
  • Uniprot No.：
  • 别名：
    pax6a; pax[zf-a]; paxzf-a; si:dkeyp-46c10.1Paired box protein Pax-6; Pax[Zf-a]
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-437
  • 氨基酸序列
    MPQKEYYNRA TWESGVASMM QNSHSGVNQL GGVFVNGRPL PDSTRQKIVE LAHSGARPCD ISRILQVSNG CVSKILGRYY ETGSIRPRAI GGSKPRVATP EVVGKIAQYK RECPSIFAWE IRDRLLSEGV CTNDNIPSVS SINRVLRNLA SEKQQMGADG MYEKLRMLNG QTGTWGTRPG WYPGTSVPGQ PNQDGCQQSD GGGENTNSIS SNGEDSDETQ MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNS SSHIPISSSF STSVYQPIPQ PTTPVSFTSG SMLGRSDTAL TNTYSALPPM PSFTMANNLP MQPSQTSSYS CMLPTSPSVN GRSYDTYTPP HMQAHMNSQS MAASGTTSTG LISPGVSVPV QVPGSEPDMS QYWPRLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.
  • 基因功能参考文献：
    1. Study finds that Pax6 is initially distributed contiguously throughout a large domain of the anterior neural plate of zebrafish, including the presumptive eye fields and the dorsal diencephalon. After evagination of the optic vesicle, Pax6 becomes restricted to all proliferating cells of the pigment epithelial and neural layers of the retina. PMID: 27747397
    2. Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates. PMID: 24528677
    3. loss of Pax6b or Hb9 independently results in the loss of insulin expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation. PMID: 22426004
    4. morpholino depletion of zebrafish Pax6.2 resulted in a "small eye" phenotype, supporting a role in retinal development. PMID: 23359656
    5. The results suggest that decreased Pax6 expression is permissive for axon regeneration and extensive searching, while higher levels of Pax6 are associated with restoration of topography. PMID: 16973301
    6. This study supports the hypothesis that the Pax6 transcription factor is also a signaling molecule with direct non-cell autonomous activity. PMID: 17229313
    7. following a postulated whole-genome duplication event in an ancestral teleost, duplicates pax6a and pax6b encode transcription factors required for eye, brain, olfactory system, and pancreas development PMID: 18282108
    8. Pax6 interacts with itself via both the paired domain and the homeodomain. Pax6 interaction with itself superactivates Pax6 mediated transactivation. PMID: 11069920

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Spatially restricted regions of the neural tube.
  • 数据库链接：

    KEGG: dre:30567

    STRING: 7955.ENSDARP00000115545

    UniGene: Dr.24244