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  4. Recombinant Cowpox virus Serine proteinase inhibitor 2 (CRMA)

Recombinant Cowpox virus Serine proteinase inhibitor 2 (CRMA)

  • 货号：
    CSB-YP357101CRG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP357101CRG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP357101CRG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP357101CRG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP357101CRG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CRMA
  • Uniprot No.：
  • 别名：
    CRMA; SPI-2; CPXV207; Serine proteinase inhibitor 2; Serp-2; Serpin-2; Cytokine response modifier protein A; Hemorrhage-inducing 38 kDa protein; ICE inhibitor
  • 种属：
    Cowpox virus (strain Brighton Red) (CPV)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    MDIFREIASS MKGENVFISP PSISSVLTIL YYGANGSTAE QLSKYVEKEA DKNKDDISFK SMNKVYGRYS AVFKDSFLRK IGDNFQTVDF TDCRTVDAIN KCVDIFTEGK INPLLDEPLS PDTCLLAISA VYFKAKWLMP FEKEFTSDYP FYVSPTEMVD VSMMSMYGEA FNHASVKESF GNFSIIELPY VGDTSMVVIL PDNIDGLESI EQNLTDTNFK KWCDSMDAMF IDVHIPKFKV TGSYNLVDAL VKLGLTEVFG STGDYSNMCN SDVSVDAMIH KTYIDVNEEY TEAAAATCAL VADCASTVTN EFCADHPFIY VIRHVDGKIL FVGRYCSPTT N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a 'cross-class' interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.
  • 基因功能参考文献：
    1. The s conclude that the poxvirus-encoded serpin is necessary but not sufficient for the red pock phenotype and the anti-chemotactic capabilities on chorioallantoic membranes. PMID: 22016035
    2. crmA is a virulence factor in mice during cowpox infection; however the influence of crmA is more evident during intradermal inoculation. PMID: 19056101
  • 亚细胞定位：
    Host cytoplasm.
  • 蛋白家族：
    Serpin family, Poxviruses subfamily
  • 数据库链接：

    KEGG: vg:1486086