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Recombinant Conus vexillum Alpha-conotoxin VxXXC

In Stock
  • 中文名称：
    Recombinant Conus vexillum Alpha-conotoxin VxXXC
  • 货号：
    CSB-EP314942DWK
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Alpha-conotoxin VxXXC; VxXIIC
  • 种属：
    Conus vexillum (Flag cone)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    25.3 kDa
  • 表达区域：
    1-47aa
  • 氨基酸序列
    DLRQCTRNAPGSTWGRCCLNPMCGNFCCPRSGCTCAYNWRRGIYCSC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The recombinant Conus vexillum alpha-conotoxin VxXXC is expressed in E.coli. Its expression region is the full-length amino acid sequence (1-47AA) of the Conus vexillum. It is fused with 10xHis-SUMO-tag at the N terminus and Myc-tag at the C-terminus. Its purity is greater than 85% determined by the SDS-PAGE. On the gel, this recombinant protein migrated to the molecular weight band of approximately 25 kDa. It is available now.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Conotoxin D superfamily
  • 组织特异性：
    Expressed by the venom duct.